TAP1 protein, human

Known as: Peptide Supply Factor 1, ATP-Binding Cassette Sub-Family B Member 2, ABCB2 protein, human 
Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and… (More)
National Institutes of Health

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Adenosine TriphosphatasesAntigen Presentation PathwayAntigen ProcessingAntigen-Presenting Cells
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Antigen Peptide Transporter-1

Papers overview

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Highly Cited
2007
Highly Cited
2007
Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma
HLA class I loss is a significant mechanism of immune evasion by cervical carcinoma, interfering with the development of… (More)
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2006
2006
Membrane topology of the transporter associated with antigen processing (TAP1) within an assembled functional peptide-loading complex.
The transporter associated with antigen processing (TAP) translocates antigenic peptides from the cytosol into the endoplasmic… (More)
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2005
2005
Mouse endothelial cells cross-present lymphocyte-derived antigen on class I MHC via a TAP1- and proteasome-dependent pathway.
In vivo studies suggest that vascular endothelial cells (ECs) can acquire and cross-present exogenous Ag on MHC-I but the… (More)
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2005
2005
Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I.
Before exit from the endoplasmic reticulum (ER), MHC class I molecules transiently associate with the transporter associated with… (More)
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Highly Cited
2001
Highly Cited
2001
The human cytomegalovirus gene product US6 inhibits ATP binding by TAP.
Human cytomegalovirus (HCMV) encodes several genes that disrupt the major histocompatibility complex (MHC) class I antigen… (More)
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2001
2001
TAP1 down-regulation in primary melanoma lesions: an independent marker of poor prognosis.
Melanoma tumor thickness is a major prognostic factor. Thin lesions, however, may metastasize, and sometimes thick tumors may not… (More)
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2000
2000
Transcriptional regulation of the major histocompatibility complex (MHC) class I heavy chain, TAP1 and LMP2 genes by the human papillomavirus (HPV) type 6b, 16 and 18 E7 oncoproteins
We have examined the possibility that the E7 proteins of the high-risk human papillomavirus (HPV) type 16 and 18 and the… (More)
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Highly Cited
1999
Highly Cited
1999
Lateral diffusion of GFP-tagged H2Ld molecules and of GFP-TAP1 reports on the assembly and retention of these molecules in the endoplasmic reticulum.
Lateral diffusion of GFP-tagged H2Ld molecules in the ER membrane reports on their interaction with the TAP complex during… (More)
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Highly Cited
1996
Highly Cited
1996
Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.
The immediate early protein ICP47 of herpes simplex virus (HSV) inhibits the transporter for antigen processing (TAP)-mediated… (More)
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Highly Cited
1993
Highly Cited
1993
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective
T cells detect infection of cells by recognizing peptide fragments of foreign proteins bound to class I molecules of the major… (More)
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