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TAP1 protein, human

Known as: Peptide Supply Factor 1, ATP-Binding Cassette Sub-Family B Member 2, ABCB2 protein, human 
Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and… 
National Institutes of Health

Related topics

Related topics

30 relations
Adenosine TriphosphatasesAntigen Presentation PathwayAntigen ProcessingAntigen-Presenting Cells
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Broader (1)

Antigen Peptide Transporter-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma
HLA class I loss is a significant mechanism of immune evasion by cervical carcinoma, interfering with the development of… 
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Highly Cited
2004
Highly Cited
2004
Viral degradation of the MHC class I peptide loading complex.
The murine gamma-herpesvirus-68 MK3 protein inhibits CD8(+) T cell recognition by ubiquitinating the cytoplasmic tails of… 
Highly Cited
2000
Highly Cited
2000
Transcriptional regulation of the major histocompatibility complex (MHC) class I heavy chain, TAP1 and LMP2 genes by the human papillomavirus (HPV) type 6b, 16 and 18 E7 oncoproteins
We have examined the possibility that the E7 proteins of the high-risk human papillomavirus (HPV) type 16 and 18 and the… 
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Highly Cited
1999
Highly Cited
1999
Lateral diffusion of GFP-tagged H2Ld molecules and of GFP-TAP1 reports on the assembly and retention of these molecules in the endoplasmic reticulum.
Lateral diffusion of GFP-tagged H2Ld molecules in the ER membrane reports on their interaction with the TAP complex during… 
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Highly Cited
1998
Highly Cited
1998
ER‐60, a chaperone with thiol‐dependent reductase activity involved in MHC class I assembly
The assembly of newly synthesized MHC class I molecules within the endoplasmic reticulum and their association with the… 
Highly Cited
1998
Highly Cited
1998
Different Requirements for Signal Transducer and Activator of Transcription 1α and Interferon Regulatory Factor 1 in the Regulation of Low Molecular Mass Polypeptide 2 and Transporter Associated with…
The components of the antigen processing machinery, low molecular mass polypeptide (LMP) 2 and transporter associated with… 
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Highly Cited
1994
Highly Cited
1994
Interaction of MHC class I molecules with the transporter associated with antigen processing.
The transporter associated with antigen processing (TAP) delivers cytosolic peptides into the endoplasmic reticulum (ER) where… 
Highly Cited
1994
Highly Cited
1994
Characteristics of peptide and major histocompatibility complex class I/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2).
The transporter proteins associated with antigen processing (TAP proteins) transport antigenic peptides across the endoplasmic… 
Highly Cited
1994
Highly Cited
1994
TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but…
Under most circumstances, cell surface MHC class I molecules display peptides derived from a cytosolic pool of proteins. The… 
Highly Cited
1993
Highly Cited
1993
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective
T cells detect infection of cells by recognizing peptide fragments of foreign proteins bound to class I molecules of the major… 
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