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TAP1 protein, human

Known as: Peptide Supply Factor 1, ATP-Binding Cassette Sub-Family B Member 2, ABCB2 protein, human 
Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and… Expand
National Institutes of Health

Related topics

Related topics

30 relations
Adenosine TriphosphatasesAntigen Presentation PathwayAntigen ProcessingAntigen-Presenting Cells
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Broader (1)

Antigen Peptide Transporter-1

Papers overview

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Highly Cited
2007
Highly Cited
2007
Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma
HLA class I loss is a significant mechanism of immune evasion by cervical carcinoma, interfering with the development of… Expand
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Highly Cited
2004
Highly Cited
2004
Viral degradation of the MHC class I peptide loading complex.
The murine gamma-herpesvirus-68 MK3 protein inhibits CD8(+) T cell recognition by ubiquitinating the cytoplasmic tails of… Expand
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Highly Cited
2003
Highly Cited
2003
MHC class I‐deficient metastatic tumor variants immunoselected by T lymphocytes originate from the coordinated downregulation of APM components
Previous reports from our group indicated that the MHC class I phenotype of metastatic lung colonies produced by a mouse… Expand
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Highly Cited
1998
Highly Cited
1998
ER‐60, a chaperone with thiol‐dependent reductase activity involved in MHC class I assembly
The assembly of newly synthesized MHC class I molecules within the endoplasmic reticulum and their association with the… Expand
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Highly Cited
1998
Highly Cited
1998
HLA‐A*0201 presents TAP‐dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin
Tapasin is a 48‐kDa endoplasmic reticulum (ER)‐resident glycoprotein that binds to the transporter associated with antigen… Expand
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Highly Cited
1995
Highly Cited
1995
Assembly, Intracellular Localization, and Nucleotide Binding Properties of the Human Peptide Transporters TAP1 and TAP2 Expressed by Recombinant Vaccinia Viruses (*)
The transporter associated with antigen processing (TAP) transports short peptides from the cytosol to the endoplasmic reticulum… Expand
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Highly Cited
1994
Highly Cited
1994
Interaction of MHC class I molecules with the transporter associated with antigen processing.
The transporter associated with antigen processing (TAP) delivers cytosolic peptides into the endoplasmic reticulum (ER) where… Expand
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Highly Cited
1994
Highly Cited
1994
Characteristics of peptide and major histocompatibility complex class I/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2).
The transporter proteins associated with antigen processing (TAP proteins) transport antigenic peptides across the endoplasmic… Expand
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Highly Cited
1994
Highly Cited
1994
TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but…
Under most circumstances, cell surface MHC class I molecules display peptides derived from a cytosolic pool of proteins. The… Expand
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Highly Cited
1993
Highly Cited
1993
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective
T cells detect infection of cells by recognizing peptide fragments of foreign proteins bound to class I molecules of the major… Expand
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