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TAP1 protein, human

Known as: Peptide Supply Factor 1, ATP-Binding Cassette Sub-Family B Member 2, ABCB2 protein, human 
Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and… 
National Institutes of Health

Related topics

Related topics

30 relations
Adenosine TriphosphatasesAntigen Presentation PathwayAntigen ProcessingAntigen-Presenting Cells

Broader (1)

Antigen Peptide Transporter-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
TAP1 and TAP2 polymorphism in coeliac disease
Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes… 
2003
2003
Nucleotide Interactions with Membrane-bound Transporter Associated with Antigen Processing Proteins*
The transporter associated with antigen processing (TAP) contains two nucleotide-binding domains (NBD) in the TAP1 and TAP2… 
2002
2002
High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors.
The Tap1 and Tap2 genes encoding for a heterodimeric peptide transporter play a key role in antigen processing and presentation… 
Highly Cited
2001
Highly Cited
2001
Distinct functional properties of the TAP subunits coordinate the nucleotide-dependent transport cycle
Highly Cited
1999
Highly Cited
1999
Membrane topology and dimerization of the two subunits of the transporter associated with antigen processing reveal a three-domain structure.
Presentation of peptides derived from cytosolic and nuclear proteins by MHC class I molecules requires their translocation across… 
Review
1997
Review
1997
MHC class I antigen processing pathways.
1997
1997
Major histocompatibility complex class I molecules interact with both subunits of the transporter associated with antigen processing, TAP1 and TAP2
Prior to loading antigenic peptides, assembled major histocompatibility complex (MHC) class I molecules associate with the… 
Highly Cited
1995
Highly Cited
1995
Assembly, Intracellular Localization, and Nucleotide Binding Properties of the Human Peptide Transporters TAP1 and TAP2 Expressed by Recombinant Vaccinia Viruses (*)
The transporter associated with antigen processing (TAP) transports short peptides from the cytosol to the endoplasmic reticulum… 
1994
1994
MHC-encoded TAP1 and TAP2 dimorphisms in multiple sclerosis.
1993
1993
Presentation of numerous viral peptides to mouse major histocompatibility complex (MHC) class I-restricted T lymphocytes is mediated by the human MHC-encoded transporter or by a hybrid mouse- human…
The major histocompatibility complex-encoded transporter associated with antigen processing (TAP) is required for the efficient… 
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