• Publications
  • Influence
Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.
TLDR
It is shown that the related chaperone, calreticulin, binds human class I-beta 2m dimers prior to peptide loading, suggesting that calretiulin remains associated with at least a subset of class I molecules when they, in turn, bind to TAP. Expand
Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus
  • K. Chin, P. Cresswell
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 December 2001
TLDR
The identification of a cytoplasmic antiviral protein that is induced by IFNs, by HCMV infection, and by the H CMV envelope protein, glycoprotein B (gB), which is named viperin (for virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible). Expand
Mechanisms of MHC class I--restricted antigen processing.
TLDR
A subset of the proteasome beta-subunits and one of the accessory complexes are upregulated by gamma-interferon and affect the generation of peptides to promote more efficient antigen recognition and bind lipid-based ligands within the endocytic pathway. Expand
Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.
TLDR
When expressed in the tapasin-negative .220 cell line, recombinant soluble tapasin retains its association with class I and restores class I cell surface expression and function, even though it no longer binds TAP or increases TAP levels. Expand
Assembly, transport, and function of MHC class II molecules.
  • P. Cresswell
  • Biology, Medicine
  • Annual review of immunology
  • 1994
MHC class II molecules assemble in the endoplasmic reticulum in a chaperone-mediated fashion to form a nine-chain structure consisting of three alpha beta dimers associated with an invariant chainExpand
A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes.
TLDR
The molecular cloning of tapasin revealed it to be a transmembrane glycoprotein encoded by an MHC-linked gene, a member of the immunoglobulin superfamily with a probable cytoplasmic endoplasmic reticulum retention signal. Expand
The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts.
TLDR
It is shown that the interferon-induced protein viperin inhibits influenza A virus release from the plasma membrane of infected cells, suggesting that targeting the release stage of the life cycle may affect the replication of many enveloped viruses. Expand
Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
TLDR
It is inferred that two complementary trans-acting factors mediate enhanced expression of HLA class I antigens in the hybrid, provided by a gene located on chromosome 6, derived from CEMR.3. Expand
Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT).
TLDR
A lysosomal thiol reductase optimally active at low pH and capable of catalyzing disulfide bond reduction both in vivo and in vitro is described, suggesting a potentially important role in antigen processing. Expand
Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.
TLDR
The structure revealed that tapasin interacts with both ERp57 catalytic domains, accounting for the stability of the heterodimer, and provided an example of a protein disulfide isomerase family member interacting with substrate. Expand
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