T cell differentiation

Known as: T lymphocyte differentiation, T-cell differentiation, T-lymphocyte differentiation 
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin… (More)

Topic mentions per year

Topic mentions per year

1973-2017
010020019732017

Papers overview

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Highly Cited
2009
Highly Cited
2009
Memory CD8 T cells are a critical component of protective immunity, and inducing effective memory T-cell responses is a major… (More)
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Highly Cited
2007
Highly Cited
2007
The cytokine transforming growth factor-beta (TGF-beta) converts naïve T cells into regulatory T (Treg) cells that prevent… (More)
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Highly Cited
2007
Highly Cited
2007
Regulatory CD4+ T cells (Tr cells), the development of which is critically dependent on X-linked transcription factor Foxp3… (More)
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Highly Cited
2002
Highly Cited
2002
The molecular interactions provided by the thymic microenvironment that predicate T cell development remain obscure. Here, we… (More)
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Highly Cited
2001
Highly Cited
2001
The rules that govern memory T cell differentiation are not well understood. This study shows that after antigenic stimulation na… (More)
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Highly Cited
2000
Highly Cited
2000
Targeted mutation of TGFbeta1 in mice demonstrated that TGFbeta1 is one of the key negative regulators of immune homeostasis, as… (More)
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Highly Cited
1998
Highly Cited
1998
Helper T (Th) cell differentiation is highly regulated by cytokines but initiated by mitogens. By examining gene expression in… (More)
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Highly Cited
1998
Highly Cited
1998
Differentiating cells undergo programmed alterations in their patterns of gene expression, which are often regulated by… (More)
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Highly Cited
1998
Highly Cited
1998
The c-Jun NH2-terminal kinase (JNK) signaling pathway has been implicated in the immune response that is mediated by the… (More)
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Highly Cited
1992
Highly Cited
1992
The V(D)J recombination activation gene RAG-1 was isolated on the basis of its ability to activate V(D)J recombination on an… (More)
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