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T cell differentiation

Known as: T lymphocyte differentiation, T-cell differentiation, T-lymphocyte differentiation 
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin… 
National Institutes of Health

Related topics

Related topics

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T cell lineage commitmentT cell selection
T-Cell Developmentregulation of T cell differentiation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Notch: a unique therapeutic target for immunomodulation
Under normal circumstances, the adaptive immune response to either self or harmless antigens is kept under tight control by a… 
1999
1999
Autocrine regulation of IL-12 receptor expression is independent of secondary IFN-gamma secretion and not restricted to T and NK cells.
The biological response to IL-12 is mediated through specific binding to a high affinity receptor complex composed of at least… 
1997
1997
Separately expressed T cell receptor alpha and beta chain transgenes exert opposite effects on T cell differentiation and neoplastic transformation.
Two aspects of T cell differentiation in T cell receptor (TCR)-transgenic mice, the generation of an unusual population of CD4… 
1991
1991
CD4 and CD8 are positive regulators of T cell receptor signal transduction in early T cell differentiation.
Although cortical (CD4+CD8+) thymocytes mobilize intracellular calcium poorly when CD3/TCR is ligated, we have found that murine… 
1990
1990
Nonrandom rearrangement of T cell receptor J alpha genes in bone marrow T cell differentiation cultures.
TCR J alpha genes span a distance of approximately 65 kb on mouse chromosome 14. Due to the existence of 50 to 100 discrete J… 
Review
1990
Review
1990
T-cell receptor gene rearrangements and the diagnosis of human T-cell neoplasms.
Highly Cited
1987
Highly Cited
1987
Evidence for an association between CD8 molecules and the T cell receptor complex on cytotoxic T cells.
The T cell differentiation molecule CD8 is thought to play an important role in class I major histocompatibility complex… 
Highly Cited
1986
Highly Cited
1986
Induction and blocking of cytolysis in CD2+, CD3- NK and CD2+, CD3+ cytotoxic T lymphocytes via CD2 50 KD sheep erythrocyte receptor.
The 50 KD sheep red blood cell antigen receptor CD2 is the earliest T cell differentiation marker and is present on all blood… 
1986
1986
T-cell antigen-receptor genes in autoimmune mice.
The developmental patterns of rearrangement and expression of the T-cell antigen-receptor genes are precisely regulated during T… 
1984
1984
Characterization of thymocytes expressing the common acute lymphoblastic leukemia antigen.
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