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Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV
Recovery of cytomegalovirus (CMV)-specific T-cell-mediated immunity after allogeneic hematopoietic stem cell transplantation (SCT) is critical for protection against CMV disease. The study usedExpand
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Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR
Primary human activated T lymphocytes were genetically grafted with chimeric T cell receptors (TCR). Three domain single chain (sc-) TCR as well as two chain (tc-) TCR gene constructs were derivedExpand
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Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer
We identified a tumor-associated cytotoxic T lymphocyte (CTL) epitope derived from the widely expressed human MDM2 oncoprotein and were able to bypass self-tolerance to this tumor antigen inExpand
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Flexible and sensitive method to functionally validate tumor-specific receptors via activation of NFAT.
Tumor-specific receptors may provide effective tools for anti-tumor immunogene therapy. However, the functional analysis of primary human T cells engrafted with tumor-specific receptors is laboriousExpand
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Sequence analysis of the Epstein-Barr virus (EBV) latent membrane protein-1 gene and promoter region: identification of four variants among wild-type EBV isolates.
Sequence variations in the Epstein-Barr virus (EBV) encoded latent membrane protein-1 (LMP-1) gene have been described in a Chinese nasopharyngeal carcinoma-derived isolate (CAO), and in viralExpand
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Lymphokine-activated killer cell activity Characteristics of effector cells and their progenitors in blood and spleen.
Leukocytes in blood and spleen can be activated by interleukin 2 (IL-2) to become cytotoxic to certain tumor cell lines in vitro. Recent evidence suggests that such lymphokine-activated killer (LAK)Expand
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A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes
Cloned blood lymphocytes that do not express the α- and β-chains of the T-cell receptor show MHC-unrestricted cytotoxicity. These cells carry the γ-protein, disulphide-linked either to anotherExpand
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Intrapleural administration of interleukin 2 in pleural mesothelioma: a phase I-II study.
Twenty-three patients with pleural mesothelioma stage I-IIA were entered in a study of continuous daily intrapleural infusion of interleukin 2 (IL-2) for 14 days, repeated every 4 weeks. IL-2 wasExpand
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Sequence analysis of the Epstein-Barr Virus (EBV) latent membrane protein -1 gene and promoter region: identification of four variants among wild-type EBV isolates
Sequence variations in the Epstein-Barr virus (EBV) encoded latent membrane protein-1 (LMP-1) gene have been described in a Chinese nasopharyngeal carcinoma-derived isolate (CAO), and in viralExpand
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Phase I study of subcutaneously administered recombinant human interleukin 12 in patients with advanced renal cell cancer.
A phase I study was conducted to characterize the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and pharmacokinetics of a single dose followed by three times weekly s.c. injections ofExpand
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