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T cell selection

Known as: T lymphocyte selection, T-cell selection, T-lymphocyte selection 
The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are… 
National Institutes of Health

Related topics

Related topics

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Broader (1)

T cell differentiation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.
Highly Cited
2012
Highly Cited
2012
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
Signaling via the T cell antigen receptor (TCR) during the CD4+CD8+ double-positive developmental stage determines thymocyte… 
Highly Cited
2010
Highly Cited
2010
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection
T cell selection and maturation in the thymus depends on the interactions between T cell receptors (TCRs) and different self… 
Highly Cited
2003
Highly Cited
2003
Cutting Edge: Self-Peptides Drive the Peripheral Expansion of CD4+CD25+ Regulatory T Cells 1
CD4+CD25+ regulatory T cell selection is initiated by high-specificity interactions with self-peptides in the thymus, although… 
Highly Cited
2003
Highly Cited
2003
An in Vivo Replication-important Function in the Second Coding Exon of Tat Is Constrained against Mutation despite Cytotoxic T Lymphocyte Selection*
Human and simian immunodeficiency virus (HIV/SIV) Tat proteins are specified by two coding exons. Tat functions in the… 
Highly Cited
2002
Highly Cited
2002
Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain
CD4+ T cells are positively selected in the thymus on peptides presented in the context of major histocompatibility complex class… 
Highly Cited
2000
Highly Cited
2000
Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection.
Engraftment of allogeneic bone marrow (BM) has been shown to induce tolerance to organs genotypically matched with the BM donor… 
2000
2000
Ly49A expression on T cells alters T cell selection.
Ly49 receptors are inhibitory receptors expressed on subsets of both NK cells and NK1.1(+) T cells. The function of these… 
Review
1999
Review
1999
The Thymic Repertoire of Neuroendocrine-Related Self Antigens: Biological Role in T-Cell Selection and Pharmacological Implications
Thymic epithelium, including nurse cells (TEC/TNC), as well as other thymic stromal cells (macrophages and dentritic cells… 
Highly Cited
1998
Highly Cited
1998
The Action of Bax and Bcl-2 on T Cell Selection
T cell development and selection in the thymus are shaped by the induction of apoptosis. However, a direct role in T cell… 
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