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Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection
TLDR
Serological studies on a group of 151 S. mansoni‐infected individuals resident in an endemic areain Machakos District, Kenya found antibody levels against various antigens before treatment were related to intensity of previous infections; antibodies in blood samples taken 6 months after treatment wererelated to cumulative reinfection rates over the following 30 months. Expand
Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals
TLDR
It is reported that the selective failure of CD4+ T cells from 59 clinically asymptomatic HIV-infected individuals to proliferate in vitro to TCR mobilization by major histocompatibility complex class II-dependent superantigens and to pokeweed mitogen (PWM) is due to an active CD4- T cell death process, with the biochemical and ultrastructural features of apoptosis. Expand
Expression of Cd28 and Cd86 by Human Eosinophils and Role in the Secretion of Type 1 Cytokines (Interleukin 2 and Interferon γ)
TLDR
The results suggest that the release of type 1 (IFN-γ and IL-2) versus type 2 cytokines by eosinophils is not only differential but also dependent on cross-regulatory signals. Expand
High-affinity IgE receptor on eosinophils is involved in defence against parasites
TLDR
Results indicate that FcεRI may play a major part in immune defence against parasites and participates in eosinophil-mediated cytotoxicity against S. mansoni. Expand
Toxoplasma gondii: characterization and localization of antigens secreted from tachyzoites.
TLDR
Observations suggest the following mechanism of Toxoplasma secretion: secreted antigens are first stored in tachyzoite-dense granules and are then released inside the parasitophorous vacuole. Expand
Characterization of a dense granule antigen of Toxoplasma gondii (GRA6) associated to the network of the parasitophorous vacuole.
TLDR
This work describes the molecular characterization of GRA6, a novel Toxoplasma gondii dense granule antigen of 32 kDa, which potentially encodes a 230-amino-acid polypeptide, does not contain any introns and seems to be present as a single copy in the genome of T. Gondii. Expand
Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion
TLDR
It is demonstrated that eos inophils, under physiological stimulation, can release significant amounts of IL-5, which may contribute to local eosinophil recruitment and activation. Expand
Schistosomes: the road from host-parasite interactions to vaccines in clinical trials.
TLDR
Recent advances are reported that substantially increase the understanding of the nature of the host innate and adaptive responses to schistosomes and on strategies elaborated by the parasite to manipulate such responses. Expand
Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis.
TLDR
A model of AIDS pathogenesis is presented that may explain several features of HIV infection, including evolution of the disease and the development of defects in nonimmunological organs. Expand
Increased secretion of tumor necrosis factor alpha and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction.
TLDR
TNF-alpha and IL-6 secretion by AM consecutively to the development of LAR in allergic subjects with asthma is demonstrated, confirming that AMs are activated after allergen challenge. Expand
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