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T cell lineage commitment

Known as: T lymphocyte lineage commitment, T-cell lineage commitment, T-lymphocyte lineage commitment 
The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. [GOC:add, ISBN:0781735149]
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

T cell differentiation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment
The mechanism of T cell precursor commitment to the or T cell lineage remains unclear. While TCR signal strength has emerged as a… 
2016
2016
T Cell Lineage Commitment and Specification
2015
2015
Regulation of T cell lineage commitment by SMAR1 during inflammatory & autoimmune diseases
Background & objectives: CD4+ T cells are involved in abnormal inflammatory responses causing adverse effects to the body. Th17… 
2015
2015
Somatic Variation of T-Cell Receptor Genes Strongly Associate with HLA Class Restriction
Every person carries a vast repertoire of CD4+ T-helper cells and CD8+ cytotoxic T cells for a healthy immune system. Somatic VDJ… 
2011
2011
TCR signaling drives early growth response 2 gene expression and enforces natural killer T cell lineage commitment (153.40)
The transcription factor PLZF is required to drive lineage diversification of would-be conventional T cells into the natural… 
Review
2011
Review
2011
T Cell Lineage Commitment: Identity and Renunciation
Precursors undertaking T cell development shed their access to other pathways in a sequential process that begins before entry… 
Highly Cited
2011
Highly Cited
2011
Deep Sequencing of the Human TCRγ and TCRβ Repertoires Suggests that TCRβ Rearranges After αβ and γδ T Cell Commitment
Deep sequencing provides new insights about T cell receptor rearrangement in humans. Feng Shui for T Cells In the ancient art of… 
Review
2009
Review
2009
Epigenetic Regulation of Cytokine Gene Expression in T Lymphocytes
The developmental program of T helper and regulatory T cell lineage commitment is governed by both genetic and epigenetic… 
Highly Cited
2005
Highly Cited
2005
Restricted STAT5 Activation Dictates Appropriate Thymic B versus T Cell Lineage Commitment1
The molecular mechanisms regulating lymphocyte lineage commitment remain poorly characterized. To explore the role of the IL7R in… 
Highly Cited
2004
Highly Cited
2004
Analysis of intergenic transcription in the human IL-4/IL-13 gene cluster.
During the differentiation of naïve CD4+ precursors to T helper 1 (Th1) or Th2 effector cells, several epigenetic changes occur… 
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