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The biology of NKT cells.
NKT cell biology has emerged as a new field of research at the frontier between innate and adaptive immunity, providing a powerful model to study fundamental aspects of the cell and structural biology of glycolipid trafficking, processing, and recognition.
Mouse CD1-specific NK1 T cells: development, specificity, and function.
The specificity and function of mouse NK1 T cells are reviewed, the relationship of this lineage to mainstream T cells and NK cells is discussed, and the novel regulatory pathway, which straddles the innate and the adaptive immune systems, is discussed.
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Evidence is reported for microbial, antigen-specific activation of NKT cells against Gram-negative, lipopolysaccharide (LPS)-negative alpha-Proteobacteria such as Ehrlichia muris and Sphingomonas capsulata and shows that glycosylceramides are an alternative to LPS for innate recognition of the Gram- negative, LPS-negative bacterial cell wall.
An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans
The mouse thymus contains a mature T cell subset that is distinguishable from the mainstream thymocytes by several characteristics, and it is found that, whereas the beta chain V-D-J junctions are quite variable, a single invariant alpha chain V alpha 14-J281 is used by a majority of the TCRs.
The transcription factor PLZF directs the effector program of the NKT cell lineage.
CD1 recognition by mouse NK1+ T lymphocytes.
- A. Bendelac, O. Lantz, M. E. Quimby, J. Yewdell, J. Bennink, R. Brutkiewicz
- 12 May 1995
In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific, providing evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.
Lysosomal Glycosphingolipid Recognition by NKT Cells
It is suggested that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity.
A committed hemopoietic precursor to innate lymphoid cells
A novel subset of lymphoid precursors in mouse fetal liver and adult bone marrow that transiently express high amounts of PLZF, a transcription factor previously associated with NK T cell development, is identified and identified, establishing novel lineage relationships between ILC, NK and LTi cells, and identifying the common precursor to ILCs, termed ILCP.
In Vivo Identification of Glycolipid Antigen–Specific T Cells Using Fluorescent Cd1d Tetramers
- K. Benlagha, A. Weiss, A. Beavis, L. Teyton, A. Bendelac
- BiologyJournal of Experimental Medicine
- 5 June 2000
The generation and use of mouse CD1d1–glycolipid tetramers are reported, for the first time, to accurately describe, based on TCR specificity, the entire population of NKT cells in vivo and to identify a previously unrecognized population of NK1.1-negative “NKT” cells.
Distinct Functional Lineages of Human Vα24 Natural Killer T Cells
- Peter T. Lee, K. Benlagha, L. Teyton, A. Bendelac
- Biology, MedicineJournal of Experimental Medicine
- 4 March 2002
It is reported here that CD4+ and CD4−CD8− (double negative [DN]) NKT cell subsets represent functionally distinct lineages with marked differences in their profile of cytokine secretion and pattern of expression of chemokine receptors, integrins, and NK receptors.