T-Cell Development

Known as: T-Cell Differentiation, T-Lymphocyte Development, T-Cell Ontogeny 
Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the… (More)
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
The role of transforming growth factor-beta (TGF-beta) in inhibiting T cell functions has been studied with dominant-negative TGF… (More)
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Highly Cited
2003
Highly Cited
2003
T-cell defects and premature thymic atrophy occur in cancer patients and tumor-bearing animals. We demonstrate that exposure of… (More)
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Review
2003
Review
2003
CD8+ T cells are essential in the defence against viruses. Recently, peptide–HLA class I tetramers have been used to study immune… (More)
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Highly Cited
2002
Highly Cited
2002
T lymphocytes differentiate in discrete stages within the thymus. Immature thymocytes lacking CD4 and CD8 coreceptors… (More)
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Highly Cited
2002
Highly Cited
2002
T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4+ T cell generation required… (More)
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Highly Cited
1997
Highly Cited
1997
Signals from cytokine and antigen receptors play crucial roles during lymphocyte development. Mice lacking interleukin-7 receptor… (More)
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Highly Cited
1997
Highly Cited
1997
The E2A gene products, E12 and E47, are critical for proper early B-cell development and commitment to the B-cell lineage. Here… (More)
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Highly Cited
1996
Highly Cited
1996
SIGNAL transducers and activators of transcription (Stats) are activated by tyrosine phosphorylation in response to cytokines… (More)
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Highly Cited
1995
Highly Cited
1995
Itk is a T cell protein tyrosine kinase (PTK) that, along with Btk and Tec, belongs to a family of cytoplasmic PTKs with N… (More)
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Highly Cited
1993
Highly Cited
1993
The transmembrane tyrosine phosphatase CD45 is expressed in multiple isoforms on all nucleated hematopoietic cells, resulting… (More)
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