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ATM gene

Known as: ataxia telangiectasia mutated (ATM) gene, ATAXIA-TELANGIECTASIA MUTATED GENE, TEL1 
This gene is involved in apoptosis, DNA repair and cell cycle regulation.
National Institutes of Health

Related topics

Related topics

14 relations
ATM protein, humanApoptosisAtaxia TelangiectasiaAtaxia Telangiectasia Mutated Proteins

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ATM wt Allele

Papers overview

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Highly Cited
2011
Highly Cited
2011
Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks
The multifunctional Mre11-Rad50-Nbs1 (MRN) protein complex recruits ATM/Tel1 checkpoint kinase and CtIP/Ctp1 homologous… 
Review
2007
Review
2007
Saccharomyces cerevisiae Sae2- and Tel1-Dependent Single-Strand DNA Formation at DNA Break Promotes Microhomology-Mediated End Joining
Microhomology-mediated end joining (MMEJ) joins DNA ends via short stretches [5–20 nucleotides (nt)] of direct repeat sequences… 
Highly Cited
2007
Highly Cited
2007
Tel1 kinase and subtelomere‐bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast
Telomerase enables telomere length homeostasis, exhibiting increasing preference for telomeres as their lengths decline. This… 
Highly Cited
2006
Highly Cited
2006
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
One of the earliest marks of a double-strand break (DSB) in eukaryotes is serine phosphorylation of the histone variant H2AX at… 
Highly Cited
2006
Highly Cited
2006
S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association.
Highly Cited
2005
Highly Cited
2005
Rap1 prevents telomere fusions by nonhomologous end joining
Telomeres protect chromosomes from end‐to‐end fusions. In yeast Saccharomyces cerevisiae, the protein Rap1 directly binds… 
Highly Cited
2003
Highly Cited
2003
ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism.
In budding yeast, TEL1 encodes a protein closely related to ATM. Xrs2 is an Nbs1 homolog and forms a complex with Mre11 and Rad50… 
Highly Cited
2003
Highly Cited
2003
Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae
Yeast strains with mutations in both TEL1 and MEC1 have short telomeres and elevated rates of chromosome deletions. By using a… 
Highly Cited
2000
Highly Cited
2000
The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast.
The Mre11p/Rad50p/Xrs2p complex is involved in the repair of double-strand DNA breaks, nonhomologous end joining, and telomere… 
Highly Cited
1995
Highly Cited
1995
TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
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