Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules
The vast majority of immature CD4+8+ T cells that express the transgenic TCR were deleted in the male transgenic mouse, and the majority of T cells spared by this deletion process expressed a high level of the transgen TCR.
Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
There is direct evidence that positive selection of antigen-specific, class I MHC-restricted CD4−8+ T cells in the thymus requires the specific interaction of the αβ TCR with the restricting classI MHC molecule.
RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation.
TNF Type 2 Receptor (p75) Lowers the Threshold of T Cell Activation1
The role of TNFR2 (p75) as a putative costimulatory receptor for T cell activation was examined and it was found that p75 deficiency in CD8+ T cells increased the requirements for TCR agonist approximately 5-fold.
Specific antiviral activity demonstrated by TGTP, a member of a new family of interferon-induced GTPases.
It is found that TGTP is strongly induced by endogenous IFN-alpha beta produced in response to standard lipofection of plasmid DNA or polyinosinic polycytidylic acid, placing TGTP among a small family of innate antiviral agents and has implications for the functions of other members of this family of GTPases.
Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells.
The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4+8- or CD4-8+ mature T cells.
The thymus selects the useful, neglects the useless and destroys the harmful.
The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis.
Isolation of a gene encoding a developmentally regulated T cell-specific protein with a guanine nucleotide triphosphate-binding motif.
The discovery of Tgtp resolves a subfamily of molecules with GTP binding motifs and apparent lymphoid lineage-restricted expression and is suggested that TGTP may have an important function in T cell development and/or T cell activation.
Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells
The results indicate that the specific interaction of the T-cell receptor on immature thymocyte with thymic major histocompatibility complex antigens determines the differentiation of CD4+8+ thymocytes into either CD4-8– or CD4–8+ mature T cells.