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T-Lymphocyte Activation Antigen CD80, human

Known as: CD28LG, CD80 Antigen, CD28 Antigen Ligand 1 
T-lymphocyte activation antigen CD80 (288 aa, ~33 kDa) is encoded by the human CD80 gene. This protein is involved in the regulation of T-cell… 
National Institutes of Health

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22 relations
B-LymphocytesCD80 geneCD80 wt AlleleCell Adhesion

Broader (1)

CD80 Antigens

Papers overview

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Highly Cited
2012
Highly Cited
2012
Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-κB-dependent pathway.
BACKGROUND Recent studies suggest that CD80 (also known as B7.1) is expressed on podocytes in minimal-change disease (MCD) and… 
Highly Cited
2008
Highly Cited
2008
Immunogenicity and immunomodulatory effects of amnion-derived multipotent progenitor cells.
Highly Cited
1997
Highly Cited
1997
Expression of costimulatory molecules B7‐1 (CD80) and B7‐2 (CD86) on human hepatocellular carcinoma
Costimulation mediated by costimulatory molecules, such as B7‐1 and B7‐2, which are ligands for the CD28/cytolytic T lymphocyte… 
Highly Cited
1997
Highly Cited
1997
Immunomodulatory effects of a plasmid expressing B7‐2 on human immunodeficiency virus‐1‐specific cell‐mediated immunity induced by a plasmid encoding the viral antigen
B7 co‐stimulation is essential for activating resting T cells following antigen recognition by the T cell receptor. To determine… 
Highly Cited
1996
Highly Cited
1996
Covalent Dimerization of CD28/CTLA-4 and Oligomerization of CD80/CD86 Regulate T Cell Costimulatory Interactions*
T lymphocyte receptors CD28 and CTLA-4 bind costimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells and… 
Highly Cited
1996
Highly Cited
1996
IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.
A number of cytokines and costimulatory molecules involved in immune activation have recently been identified including IL-12, a… 
Highly Cited
1995
Highly Cited
1995
Costimulatory requirements of naive CD4+ T cells. ICAM-1 or B7-1 can costimulate naive CD4 T cell activation but both are required for optimum response.
Efficient initiation of a CD4 T cell response requires both activation through the TCR and costimulation provided by molecules on… 
Highly Cited
1995
Highly Cited
1995
Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies.
Antigen-specific T cell activation depends initially on the interaction of the T cell receptor (TCR) with peptide/MHC. In… 
Highly Cited
1995
Highly Cited
1995
Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation
The co‐stimulatory B7 molecules (B7‐1 and B7‐2) are expressed on professional antigen‐presenting cells in mice. In this study, we… 
Highly Cited
1994
Highly Cited
1994
Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1
T cell surface receptors CD28 and CTLA-4 are homologous members of the immunoglobulin superfamily (IgSF), each comprising a… 
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