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Uric acid and cardiovascular risk.
This review summarizes relevant studies concerning uric acid and possible links to hypertension, renal disease, and cardiovascular disease and presents current evidence. Expand
Fructose consumption as a risk factor for non-alcoholic fatty liver disease.
- Xiaosen Ouyang, P. Cirillo, +5 authors M. Abdelmalek
- Biology, Medicine
- Journal of hepatology
- 1 June 2008
The pathogenic mechanism underlying the development of NAFLD may be associated with excessive dietary fructose consumption, and fructose resulted in dose-dependent increase in KHK protein and activity. Expand
A causal role for uric acid in fructose-induced metabolic syndrome.
- T. Nakagawa, Hanbo Hu, +9 authors Richard J. Johnson
- Biology, Medicine
- American journal of physiology. Renal physiology
- 1 March 2006
The first evidence that uric acid may be a cause of metabolic syndrome is provided, possibly due to its ability to inhibit endothelial function, as well as a reduced vasodilatory response of aortic artery rings to acetylcholine. Expand
IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly.
Given the strong association between proinflammatory cytokines and complications common in end-stage renal disease, such as vascular calcification and wasting, the potential role of both general and targeted anticytokine treatment strategies in ESRD patients needs further evaluation. Expand
Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
It is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy. Expand
A role for uric acid in the progression of renal disease.
- D. Kang, T. Nakagawa, +6 authors Richard J. Johnson
- Journal of the American Society of Nephrology…
- 1 December 2002
Hyperuricemia accelerates renal progression in the RK model via a mechanism linked to high systemic BP and COX-2-mediated, thromboxane-induced vascular disease and provides direct evidence that uric acid may be a true mediator of renal disease and progression. Expand
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Mild hyperuricemia causes hypertension and renal injury in the rat via a crystal-independent mechanism, with stimulation of the renin-angiotensin system and inhibition of neuronal NO synthase. Expand
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
- Richard J. Johnson, M. Segal, +6 authors L. Sánchez-Lozada
- The American journal of clinical nutrition
- 1 October 2007
It is suggested that high intakes of fructose in African Americans may explain their greater predisposition to develop cardiorenal disease, and a list of testable predictions to evaluate this hypothesis is provided. Expand
Evolving importance of kidney disease: from subspecialty to global health burden
Strong, graded, and consistent associations exist between clinical prognosis and two hallmarks of chronic kidney disease: reduced glomerular filtration rate and increased urinary albumin excretion. Expand
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
In patients with NAFLD, daily fructose ingestion is associated with reduced hepatic steatosis but increased fibrosis, a readily modifiable environmental risk factor that may ameliorate disease progression in patients withNAFLD. Expand