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Simvastatin

Known as: [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate, 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one, Simvastatine 
A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
BACKGROUND Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Results of previous randomised trials have shown that interventions that lower LDL cholesterol concentrations can… Expand
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Review
2004
Review
2004
The Adult Treatment Panel III (ATP III) of the National Cholesterol Education Program issued an evidence-based set of guidelines… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Individuals with diabetes are at increased risk of cardiovascular morbidity and mortality, although typically their… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Throughout the usual LDL cholesterol range in Western populations, lower blood concentrations are associated with… Expand
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Highly Cited
2002
Highly Cited
2002
Background Throughout the usual LDL cholesterol range in Western populations, lower blood concentrations are associated with… Expand
Review
2002
Review
2002
Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an ongoing inflammatory response. Recent… Expand
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Highly Cited
1997
Highly Cited
1997
OBJECTIVE To assess in diabetic patients with coronary heart disease (CHD) the effect of cholesterol lowering with simvastatin on… Expand
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Highly Cited
1994
Highly Cited
1994
Drug therapy for hypercholesterolaemia has remained controversial mainly because of insufficient clinical trial evidence for… Expand
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