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Simvastatin

Known as: [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate, 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one, Simvastatine 
A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Summary Background After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction… Expand
Is this relevant?
Review
2019
Review
2019
There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein cholesterol) to reduce cardiovascular… Expand
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Review
2016
Review
2016
Severe influenza remains unusual in its virulence for humans. Complications or ultimately death arising from these infections are… Expand
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Highly Cited
2011
Highly Cited
2011
Summary Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
CONTEXT Evidence suggests that more intensive lowering of low-density lipoprotein cholesterol (LDL-C) than is commonly applied… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Individuals with diabetes are at increased risk of cardiovascular morbidity and mortality, although typically their… Expand
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Highly Cited
2003
Highly Cited
2003
The primary objective of this 6-week, parallel-group, open-label, randomized, multicenter trial was to compare rosuvastatin with… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Throughout the usual LDL cholesterol range in Western populations, lower blood concentrations are associated with… Expand
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Highly Cited
1997
Highly Cited
1997
OBJECTIVE To assess in diabetic patients with coronary heart disease (CHD) the effect of cholesterol lowering with simvastatin on… Expand
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Highly Cited
1994
Highly Cited
1994
Drug therapy for hypercholesterolaemia has remained controversial mainly because of insufficient clinical trial evidence for… Expand
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