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Simvastatin

Known as: [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate, 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one, Simvastatine 
A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active… 
National Institutes of Health

Related topics

Related topics

42 relations
24 HR Niacin 1000 MG / Simvastatin 20 MG Extended Release Oral Tablet [Simcor]AmprenavirCYP3A7 protein, humanCoronary Artery Disease

Broader (4)

Anticholesteremic AgentsHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsLovastatin

Narrower (7)

MK-733SynvinolinVytorinZocor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Extract from :
There is little evidence to guide management of patients in ‘younger patients with hypertension’, that is, younger than the… 
Highly Cited
2009
Highly Cited
2009
Effect of intensive statin therapy on regression of coronary atherosclerosis in patients with acute coronary syndrome: a multicenter randomized trial evaluated by volumetric intravascular ultrasound…
Review
2009
Review
2009
The CD40/CD40 ligand system: linking inflammation with atherothrombosis.
Review
2006
Review
2006
Pharmacogenomics of human OATP transporters
Organic anion transporting polypeptides (OATPs) mediate the uptake of a broad range of compounds into cells. Substrates for… 
Review
2005
Review
2005
Cholesterol in Alzheimer's disease
Highly Cited
2002
Highly Cited
2002
Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26‐week randomized, placebo‐controlled, double‐blind trial
In a randomized, placebo‐controlled, double‐blind study, we investigated whether statins alter cholesterol metabolites and reduce… 
Review
2000
Review
2000
Non-lipid-related effects of statins
The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on coronary events have… 
Highly Cited
1997
Highly Cited
1997
Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S)
BACKGROUND The Scandinavian Simvastatin Survival Study (4S) demonstrated pronounced reductions in mortality and major coronary… 
Review
1994
Review
1994
Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection.
A ngiotensin-converting enzyme (ACE) inhibitors are commonly used drugs in the management of a variety of cardiovascular diseases… 
Highly Cited
1975
Highly Cited
1975
Depressant action of TRH, LH-RH and somatostatin on activity of central neurones
THREE structurally identified hypothalamic-adenohypophy-seal regulatory peptides—thyrotropin-releasing hormone (TRH)1,2… 
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