Simvastatin

Known as: [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate, 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one, Simvastatine 
A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1966-2017
010002000300019662017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
A high prevalence of vascular calcification (VC) and a high incidence of cardiovascular events are two key complications of… (More)
Is this relevant?
Review
2017
Review
2017
Non-alcoholic fatty liver disease (NAFLD), the most common liver disease, is characterized by accumulation of fat (>5% of the… (More)
  • figure 1
  • figure 3
  • figure 2
  • table 1
  • figure 5
Is this relevant?
Review
2016
Review
2016
 
Is this relevant?
Highly Cited
2011
Highly Cited
2011
BACKGROUND Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
BACKGROUND Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipoprotein (LDL) cholesterol when added… (More)
  • figure 1
  • table 1
  • table 2
  • table 2
  • figure 2
Is this relevant?
Highly Cited
2005
Highly Cited
2005
CONTEXT Evidence suggests that more intensive lowering of low-density lipoprotein cholesterol (LDL-C) than is commonly applied… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2004
Highly Cited
2004
CONTEXT Limited data are available evaluating how the timing and intensity of statin therapy following an acute coronary syndrome… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
Highly Cited
2003
Highly Cited
2003
BACKGROUND Individuals with diabetes are at increased risk of cardiovascular morbidity and mortality, although typically their… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2002
Highly Cited
2002
  • Lancet
  • 2002
BACKGROUND Throughout the usual LDL cholesterol range in Western populations, lower blood concentrations are associated with… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
BACKGROUND Both lipid-modifying therapy and antioxidant vitamins are thought to have benefit in patients with coronary disease… (More)
Is this relevant?