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Simvastatin

Known as: [1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate, 2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one, Simvastatine 
A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus. Hydrolyzed in vivo to an active… 
National Institutes of Health

Related topics

Related topics

42 relations
24 HR Niacin 1000 MG / Simvastatin 20 MG Extended Release Oral Tablet [Simcor]AmprenavirCYP3A7 protein, humanCoronary Artery Disease

Broader (4)

Anticholesteremic AgentsHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic AgentsLovastatin

Narrower (7)

MK-733SynvinolinVytorinZocor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Association between Aspirin Therapy and Clinical Outcomes in Patients with Non-Obstructive Coronary Artery Disease: A Cohort Study
Background Presence of non-obstructive coronary artery disease (CAD) is associated with increased prescription of cardiovascular… 
2014
2014
Use of Proton Pump Inhibitors Correlates with Increased Risk of Pancreatic Cancer: A Case-Control Study in Taiwan
Shih-Wei Lai Fung-Chang Sung3,4, Cheng-Li Lin3,4, Kuan-Fu Liao5,6 School of Medicine, and 3 2 4 5Graduate Institute of Integrated… 
2014
2014
Evaluation of a Patient With Spinal Cord Infarction After a Hypotensive Episode
Case Description A 72-year-old man with past medical history significant for peripheral vascular disease, bilateral carotid… 
Review
2012
Review
2012
Peer Review History Title (provisional) Do Statins Improve Outcomes in Patients with Asthma on Inhaled Corticosteroid Therapy? a Retrospective Cohort Analysis Authors
GENERAL COMMENTS There have been several studies that have suggest that statin medications have anti-inflammatory properties… 
2011
2011
Going home on the right medications: prescription errors and transitions of care.
  • J. KahnD. Angus
  • Journal of the American Medical Association (JAMA…
  • 2011
  • Corpus ID: 26372258
TRANSITIONS OF CARE—WHEN PATIENTS MOVE ACROSS care sites within the health system—pose both an opportunity and a threat to… 
2009
2009
Return of the rat
European investment could see knock-out rats catching up with mutant mice in medical research. 
2006
2006
Stroke--an equal opportunity for the initiation of statin therapy.
Given the disparity in the numbers of cerebrovascular and cardiovascular clinical trials and the similarities in the… 
2001
2001
Cracking down on caveolin: role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in modulating edothelial cell nitric oxide production.
One of the most effective approaches in the treatment of atherosclerosis has been the use of 3-hydroxy-3-methylglutaryl–coenzyme… 
1998
1998
Effects of atorvastatin on serum lipids of patients with familial hypercholesterolaemia
Hoogerbrugge N (University Hospital Dijkzigt, Rotterdam, the Netherlands). Effects of atorvastatin on serum lipids of patients… 
1992
1992
Asymmetric Synthesis of Calyculin A. 3. Assemblage of the Calyculin Skeleton and the Introduction of a New Phosphate Monoester Synthesis
The synthesis of a fully protected analogue of calyculin A has been accomplished using a Wittig reaction to couple fragments…