Lovastatin

Known as: 6-alpha-methylcompactin, 6alpha-Methylcompactin, 6?-methylcompactin 
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Neurofibromatosis Type 1 (NF1) is a common neurological disorder caused by mutations in the gene encoding Neurofibromin, a p21Ras… (More)
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Review
2003
Review
2003
In the 1950s and 1960s, it became apparent that elevated concentrations of plasma cholesterol were a major risk factor for the… (More)
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Highly Cited
2003
Highly Cited
2003
CONTEXT To enhance the effectiveness of diet in lowering cholesterol, recommendations of the Adult Treatment Panel III of the… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE Animal research and cross-sectional studies suggest that serum lipid concentrations may influence cognitive function… (More)
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Highly Cited
1999
Highly Cited
1999
In this paper we present the finding that lovastatin arrests cells by inhibiting the proteasome, which results in the… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Oxidized low-density lipoprotein (ox-LDL) causes endothelial dysfunction in part by decreasing the availability of… (More)
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Highly Cited
1997
Highly Cited
1997
This study explores the role of mevalonate inhibitors in the activation of NF-kbeta and the induction of inducible nitric oxide… (More)
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Highly Cited
1996
Highly Cited
1996
Lovastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (the major regulatory enzyme of the… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND HMG CoA reductase inhibitors (or statins), a new class of lipid-lowering compounds, have raised expectations for more… (More)
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Highly Cited
1991
Highly Cited
1991
Synchronization of mammalian cells is essential for investigations involving cell proliferation. A simple method for obtaining… (More)
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