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Lovastatin

Known as: 6-alpha-methylcompactin, 6alpha-Methylcompactin, 6?-methylcompactin 
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
&NA; Recently, concerns regarding the safety of red yeast rice (RYR) have been raised after the publication of some case reports… Expand
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Review
2003
Review
2003
  • J. Tobert
  • Nature Reviews Drug Discovery
  • 2003
  • Corpus ID: 3344720
In the 1950s and 1960s, it became apparent that elevated concentrations of plasma cholesterol were a major risk factor for the… Expand
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Highly Cited
2003
Highly Cited
2003
CONTEXT To enhance the effectiveness of diet in lowering cholesterol, recommendations of the Adult Treatment Panel III of the… Expand
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Highly Cited
1999
Highly Cited
1999
Polyketides, the ubiquitous products of secondary metabolism in microorganisms, are made by a process resembling fatty acid… Expand
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Highly Cited
1998
Highly Cited
1998
The objective of this multicenter, randomized, open-label, parallel-group, 8-week study was to evaluate the comparative dose… Expand
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Highly Cited
1997
Highly Cited
1997
This study explores the role of mevalonate inhibitors in the activation of NF-kbeta and the induction of inducible nitric oxide… Expand
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Highly Cited
1996
Highly Cited
1996
Lovastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (the major regulatory enzyme of the… Expand
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Highly Cited
1994
Highly Cited
1994
BACKGROUND HMG CoA reductase inhibitors (or statins), a new class of lipid-lowering compounds, have raised expectations for more… Expand
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Highly Cited
1991
Highly Cited
1991
Synchronization of mammalian cells is essential for investigations involving cell proliferation. A simple method for obtaining… Expand
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Highly Cited
1980
Highly Cited
1980
Mevinolin, a fungal metabolite, was isolated from cultures of Aspergillus terreus. The structure and absolute configuration of… Expand
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