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Lovastatin

Known as: 6-alpha-methylcompactin, 6alpha-Methylcompactin, 6?-methylcompactin 
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is… 
National Institutes of Health

Related topics

Related topics

41 relations
24 HR Lovastatin 20 MG / Niacin 500 MG Extended Release Oral Tablet [Advicor]CYP3A7 protein, humanCoronary Artery DiseaseDrug Allergy

Narrower (17)

6-hydroxyisocompactinL 157012L 647318L 669262

Broader (5)

Anticholesteremic AgentsEnzyme InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsNaphthalenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
[Thrombocytic hemostasis in hypertensive patients with metabolic syndrome and its correction with lovastatin].
The objective of the study was to evaluate the efficiency of lovastatin correction of dyslipidemia and impaired intravascular… 
2003
2003
Antibacterial screening of Citrullus colocynthis.
Crude ethanolic extracts of fruits, leaves, stems and roots of Citrullus colocynthis Schrad were examined for their antibacterial… 
Highly Cited
1997
Highly Cited
1997
Microsample determination of lovastatin and its hydroxy acid metabolite in mouse and rat plasma by liquid chromatography/ionspray tandem mass spectrometry.
A sensitive and specific method was developed and validated to quantitate lovastatin and its hydroxy acid in mouse and rat plasma… 
1997
1997
Purification and Characterization of a Lovastatin Esterase from Clonostachys compactiuscula
An esterase from the fungus Clonostachys compactiuscula selectively hydrolyzes lovastatin, a clinically useful… 
Highly Cited
1990
Highly Cited
1990
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.
A series of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)- enoates (-heptanoates) 1 and 2 have been prepared and tested… 
1990
1990
Lovastatin-induced acute rhabdomyolysis.
Severe rhabdomyolysis complicated by respiratory and renal failure developed three weeks after initiation of low dose lovastatin… 
Highly Cited
1990
Highly Cited
1990
Primary hypertriglyceridemia with borderline high cholesterol and elevated apolipoprotein B concentrations. Comparison of gemfibrozil vs lovastatin therapy.
  • G. VegaS. Grundy
  • Journal of the American Medical Association (JAMA…
  • 1990
  • Corpus ID: 5721745
A common pattern of dyslipidemia is elevated levels of plasma triglyceride, borderline high total cholesterol, reduced high… 
1988
1988
3-Hydroxy-3-methylglutaryl-coenzyme A reductase of the sea urchin embryo. Deduced structure and regulatory properties.
3-Hydroxy-3-methylglutaryl-coenzyme A reductase activity is developmentally regulated in the sea urchin Strongylocentrotus… 
1985
1985
Role of mevalonate in regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cultured cells and their cytoplasts.
H4-II-E-C3 hepatoma cells in culture respond to lipid-depleted media and to mevinolin with increased sterol synthesis from [14C… 
1983
1983
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver.
Addition of cholestyramine or cholestyramine plus mevinolin to the diet has been reported to increase the activity and mass of…