Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition.

@article{Lee2007ImprovingTR,
  title={Improving the ratio of monacolin K to citrinin production of Monascus purpureus NTU 568 under dioscorea medium through the mediation of pH value and ethanol addition.},
  author={Chun-Lin Lee and Hsi-Kai Hung and Jyh-Jye Wang and Tzu-Ming Pan},
  journal={Journal of agricultural and food chemistry},
  year={2007},
  volume={55 16},
  pages={
          6493-502
        }
}
Using dioscorea root as substrate of Monascus species was found to stimulate monacolin K (cholesterol-lowering agent) formation in our previous study, but the mycotoxin-citrinin has never been studied. This study used dioscorea root as the liquid medium to culture Monascus purpureus NTU 568 using a 6.6 L jar fermentor. Culture pH value, dioscorea concentration, and ethanol concentration were used as the factors of response surface methodology (RSM) to investigate the optimal culture condition… CONTINUE READING
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