Hydroxymethylglutaryl-CoA Reductase Inhibitors

Known as: HMG-CoA reductase inhibitors, Inhibitors, Hydroxymethylglutaryl-CoA Reductase, Reductase Inhibitors, Hydroxymethylglutaryl-CoA 
Any of a group of drugs that lower the amount of cholesterol and certain fats in the blood. Statins inhibit a key enzyme that helps make cholesterol… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1966-2017
050019662017

Papers overview

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Review
2015
Review
2015
Alzheimer's disease is the most common cause of dementia and occurs commonly in patients 65 and older. There is an urgent need to… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND In patients with established cardiovascular disease, residual cardiovascular risk persists despite the achievement of… (More)
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2006
2006
OBJECTIVES To characterize the relationship between hydroxymethylglutaryl-CoA reductase inhibitors (statins) and outcomes in… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Results of previous randomised trials have shown that interventions that lower LDL cholesterol concentrations can… (More)
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Highly Cited
2004
Highly Cited
2004
CONTEXT Statin drugs reduce both atherogenic lipoproteins and cardiovascular morbidity and mortality. However, the optimal… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Individuals with diabetes are at increased risk of cardiovascular morbidity and mortality, although typically their… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Recent studies have supported the hypothesis that calcific aortic stenosis is the product of an active inflammatory… (More)
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Highly Cited
2001
Highly Cited
2001
HMG-CoA reductase inhibitors (statins) have been developed as lipid-lowering drugs and are well established to reduce morbidity… (More)
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Highly Cited
1998
Highly Cited
1998
-Macrophages secrete matrix metalloproteinases (MMPs) that may weaken the fibrous cap of atherosclerotic plaque, predisposing its… (More)
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