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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Known as:
HMG-CoA reductase inhibitors
, Inhibitors, Hydroxymethylglutaryl-CoA Reductase
, Reductase Inhibitors, Hydroxymethylglutaryl-CoA
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Any of a group of drugs that lower the amount of cholesterol and certain fats in the blood. Statins inhibit a key enzyme that helps make cholesterol…
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National Institutes of Health
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Related topics
Related topics
34 relations
Narrower (28)
6-hydroxyisocompactin
Amlodipine / atorvastatin
Atorvastatin calcium
BMY 21950
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Cholesterol
Hydroxymethylglutaryl-CoA reductase
In Blood
aspects of radiation effects
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment
A. Wiegman
,
S. Gidding
,
+29 authors
O. Wiklund
European Heart Journal
2015
Corpus ID: 215657524
Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart disease (CHD). Globally, one baby is…
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Review
2014
Review
2014
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial…
M. Cuchel
,
E. Bruckert
,
+28 authors
M. Cuchel
European Heart Journal
2014
Corpus ID: 5892218
Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated…
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Review
2014
Review
2014
The pharmacology of statins.
C. Sirtori
Pharmacological Research
2014
Corpus ID: 29357197
Review
2001
Review
2001
Statins: mechanism of action and effects
C. Stancu
,
A. Sima
Journal of Cellular and Molecular Medicine
2001
Corpus ID: 9017852
The beneficial effects of statins are the result of their capacity to reduce cholesterol biosyntesis, mainly in the liver, where…
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Review
2000
Review
2000
Current perspectives on statins.
D. Maron
,
S. Fazio
,
M. Linton
Circulation
2000
Corpus ID: 2561907
Statins (HMG-CoA reductase inhibitors) are used widely for the treatment of hypercholesterolemia. They inhibit HMG-CoA reductase…
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Highly Cited
1998
Highly Cited
1998
Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.
U. Laufs
,
V. L. Fata
,
J. Plutzky
,
J. Liao
Circulation
1998
Corpus ID: 1654977
BACKGROUND Oxidized low-density lipoprotein (ox-LDL) causes endothelial dysfunction in part by decreasing the availability of…
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Highly Cited
1998
Highly Cited
1998
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.
M. Endres
,
U. Laufs
,
+4 authors
J. Liao
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 19848447
The treatment of ischemic strokes is limited to prophylactic agents that block the coagulation cascade. Here, we show that…
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Highly Cited
1998
Highly Cited
1998
Effect of HMG-CoA reductase inhibitors on coronary artery disease as assessed by electron-beam computed tomography.
T. Callister
,
P. Raggi
,
B. Cooil
,
N. J. Lippolis
,
D. Russo
New England Journal of Medicine
1998
Corpus ID: 33155059
BACKGROUND Angiographic studies of the regression of coronary artery disease are invasive and costly, and they permit only…
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Highly Cited
1997
Highly Cited
1997
Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.
Carole L Wilson
,
K. Heppner
,
P. Labosky
,
B. Hogan
,
L. Matrisian
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 31916968
Matrix metalloproteinases (MMPs) classically have been implicated in basement membrane destruction associated with late-stage…
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Highly Cited
1994
Highly Cited
1994
Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia.
K. Egashira
,
Y. Hirooka
,
+4 authors
A. Takeshita
Circulation
1994
Corpus ID: 17625306
BACKGROUND This study aimed to determine if cholesterol-lowering therapy improves endothelium-dependent coronary vasomotion in…
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