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Amprenavir

Known as: (3S)-Tetrahydro-3-furanyl ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(phenylmethyl)propyl)carbamate, APV, amprenavir [Chemical/Ingredient] 
A synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.
National Institutes of Health

Related topics

Related topics

47 relations
12 HR Propafenone Hydrochloride 225 MG Extended Release Oral CapsuleAmprenavir or Fosamprenavir:Susc:Pt:Isolate:OrdQn:GenotypingAmprenavir:ACnc:Pt:Ser/Plas:QnAmprenavir:MCnc:Pt:Ser/Plas:Qn

Broader (6)

Anti-HIV AgentsAntibiotics, AntitubercularCarbamatesHIV Protease Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Molecular dynamics and free energy studies on the wild-type and double mutant HIV-1 protease complexed with amprenavir and two amprenavir-related inhibitors: mechanism for binding and drug resistance…
The V82F/I84V double mutation is considered as the key residue mutation of the HIV-1 protease drug resistance because it can… 
Highly Cited
2001
Highly Cited
2001
Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus.
Ongoing neurogenesis in the adult hippocampal dentate gyrus (DG) generates a substantial population of young neurons. This… 
Highly Cited
1998
Highly Cited
1998
Exercise Capacity in Patients With Chronic Heart Failure Regular Physical Exercise Corrects Endothelial Dysfunction and Improves
Copyright © 1998 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online Circulation is published by the… 
Highly Cited
1991
Highly Cited
1991
Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus.
1. The effects of metabotropic glutamate receptor agonists on excitatory synaptic transmission in the CA1 region of rat… 
Highly Cited
1991
Highly Cited
1991
Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices
Highly Cited
1990
Highly Cited
1990
Amino acid‐mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord.
1. Fast excitatory postsynaptic potentials (EPSPs) evoked by stimulation of A delta and C fibres were examined by intracellular… 
Highly Cited
1989
Highly Cited
1989
Glutamate receptor agonists increase the expression of Fos, Fra, and AP‐1 DNA binding activity in the mammalian brain
Administration of convulsant doses of Metrazole (pentylenetetrazol) and picrotoxin, as well as maximal electroshock, results in a… 
Highly Cited
1987
Highly Cited
1987
N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
The optic tecta of surgically produced three-eyed tadpoles were chronically exposed to the N-methyl-D-aspartate (NMDA) receptor… 
Highly Cited
1987
Highly Cited
1987
N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture.
The ability of several glutamate receptor antagonists to reduce hypoxic cortical neuronal injury was quantitatively examined in… 
Highly Cited
1986
Highly Cited
1986
The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells
L-Glutamic, L-aspartic acids and a number of their structural analogs, including quisqualic, kainic, ibotenic, quinolinic, and N… 
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