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MK-733

Known as: MK 733, MK733 
National Institutes of Health

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Simvastatin

Papers overview

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1992
1992
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin and the human lens. Clinical results of a 3-year follow-up.
Simavastatin (MK-733, Zocor, CAS 79902-63-9), a new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, was… 
1991
1991
Bioconversion of the sodium salt of Simvastatin (MK-733) to 6-desmethyl-6-α-hydroxymethyl Simvastatin
SummaryAn actinomycete (MA 6474, ATCC 53828) isolated from a soil sample (Mutare, Zimbabwe) was found to biotransform the sodium… 
1991
1991
L-669,262, a potent HMG-CoA reductase inhibitor.
The microbial transformation of simvastatin (MK-733) by Nocardia autotrophica subspecies amethystina yielded iso-simvastatin-6… 
1991
1991
Metabolic fate of 2,2-dimethylbutyryl moiety of simvastatin in rats: Identification of metabolites by gas chromatography/ mass spectrometry
SummaryMetabolic pathways of simvastatin (MK-733), a lactone prodrug of an inhibitor of HMG-CoA reductase, were elucidated in… 
1990
1990
Effects of simvastatin (MK-733) on branched pathway of mevalonate.
The effects of simvastatin (MK-733), a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, on the branched pathway of… 
1990
1990
[Simvastatin (MK-733), a new HMG-CoA reductase inhibitor, in the treatment of hypercholesterolemia in elderly patients with atherosclerosis].
PURPOSE To evaluate the efficacy and tolerability of simvastatin, a new and potent HMG-CoA reductase inhibitor, in the treatment… 
1990
1990
[Evaluation of tolerance, efficacy and safety of 3-year simvastatin use in the treatment of primary hypercholesterolemia].
Simvastatin (synvinolin MK-733) is a potent inhibitor of 3-HMG-CoA-reductase, the key enzyme for cholesterol biosynthesis. To… 
1990
1990
Bezafibrate and simvastatin in the treatment of primary hypercholesterolaemia (MK-733)
S Air Med J 1990; 77: 500-503. Simvastatin, a new 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor, was compared to… 
1989
1989
Low-dose effect of simvastatin (MK-733) on serum lipids, lipoproteins, and apolipoproteins in patients with hypercholesterolemia.
The effects of simvastatin (MK-733), a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on serum lipids… 
1988
1988
Preventive effect of MK-733 on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in JW rabbits
The preventive effect of MK-733 (Simvastatin), a potent inhibitor of HMG-CoA reductase, on hypercholesterolemia and… 
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