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Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease
TLDR
There is an urgent worldwide need for diagnostic screening together with early and aggressive treatment of this extremely high-risk condition, familial hypercholesterolaemia.
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European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular…
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Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline.
TLDR
These guidelines recommend that the treatment goal in patients with moderate hypertriglyceridemia be a non-high-density lipoprotein cholesterol level in agreement with National Cholesterol Education Program Adult Treatment Panel guidelines and that a fibrate should be used as a first-line agent.
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Simvastatin with or without ezetimibe in familial hypercholesterolemia.
TLDR
In patients with familial hypercholesterolemia, combined therapy with ezetimibe and simVastatin did not result in a significant difference in changes in intima-media thickness, as compared with simvastatin alone, despite decreases in levels of LDL cholesterol and C-reactive protein.
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The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk.
TLDR
Investigations assessing the impact of anti-TNF agents on intermediary metabolism suggest that TNF-alpha blockade may improve insulin resistance and lipid profiles in patients with chronic inflammatory diseases.
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The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management.
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TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans
TLDR
Polymorphisms in TLR4 exemplify how the interaction between the authors' innate immune system and the infectious pressures in particular environments may have shaped the genetic variations and function of their immune system during the out-of-Africa migration of modern humans.
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Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty‐person/ten‐country panel
TLDR
Evidence from fundamental, epidemiological and clinical trial studies indicates that apo B is superior to any of the cholesterol indices to recognize those at increased risk of vascular disease and to judge the adequacy of lipid‐lowering therapy.
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Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial…
TLDR
The need for early identification of HoFH patients, prompt referral to specialized centres, and early initiation of appropriate treatment is highlighted, and recommendations offer guidance for a wide spectrum of clinicians who are often the first to identify patients with suspected HoFH.
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Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment
TLDR
This consensus paper aims to improve awareness of the need for early detection and management of FH children by recommending cascade screening of families using a combined phenotypic and genotypic strategy.
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