• Publications
  • Influence
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease
Aims The first aim was to critically evaluate the extent to which familial hypercholesterolaemia (FH) is underdiagnosed and undertreated. The second aim was to provide guidance for screening andExpand
  • 1,378
  • 99
  • PDF
European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular
European guidelines on cardiovascular disease prevention in clinical practice: Executive summary Authors/Task Force Members: Ian Graham (Chairperson) ∗,1, Dan Atar1, Oslo (Norway), KnutExpand
  • 726
  • 42
  • PDF
Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline.
OBJECTIVE The aim was to develop clinical practice guidelines on hypertriglyceridemia. PARTICIPANTS The Task Force included a chair selected by The Endocrine Society Clinical GuidelinesExpand
  • 433
  • 26
  • PDF
Simvastatin with or without ezetimibe in familial hypercholesterolemia.
BACKGROUND Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on theExpand
  • 803
  • 22
  • PDF
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial
Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) andExpand
  • 384
  • 17
  • PDF
A review of CETP and its relation to atherosclerosis Published, JLR Papers in Press, September 1, 2004. DOI 10.1194/jlr.R400007-JLR200
Although the atheroprotective role of HDL cholesterol (HDL-c) is well documented, effective therapeutics to selectively increase plasma HDL-c levels are not yet available. Recent progress inExpand
  • 222
  • 17
The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management.
Plasma triglyceride concentration is a biomarker for circulating triglyceride-rich lipoproteins and their metabolic remnants. Common mild-to-moderate hypertriglyceridaemia is typically multigenic,Expand
  • 285
  • 16
  • PDF
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans
Infectious diseases exert a constant evolutionary pressure on the genetic makeup of our innate immune system. Polymorphisms in Toll-like receptor 4 (TLR4) have been related to susceptibility toExpand
  • 278
  • 16
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200189-JLR200
Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is required for the biosynthesis of oleate (18:1) and palmitoleate (16:1). These monounsaturated fatty acids areExpand
  • 337
  • 14
  • PDF