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Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
TLDR
Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction, and is especially common in the elderly and is likely to increase substantially as the U.S. population ages. Expand
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
TLDR
The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock. Expand
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
TLDR
The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system was used to guide assessment of quality of evidence from high to very low and to determine the strength of recommendations. Expand
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016
TLDR
Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality. Expand
Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
TLDR
To evaluate the validity of clinical criteria to identify patients with suspected infection who are at risk of sepsis, a new model derived using multivariable logistic regression in a split sample was derived. Expand
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
TLDR
This document reflects a process whereby a group of experts and opinion leaders revisited the 1992 sepsis guidelines and found that apart from expanding the list of signs and symptoms of sepsi to reflect clinical bedside experience, no evidence exists to support a change to the definitions. Expand
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
TLDR
A hypothetical model for staging sepsis is presented, which, in the future, may better characterize the syndrome on the basis of predisposing factors and premorbid conditions, the nature of the underlying infection, the characteristics of the host response, and the extent of the resultant organ dysfunction. Expand
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
TLDR
Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality. Expand
RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis
TLDR
In this general intensive care unit population, acute kidney 'risk, injury, failure', as defined by the newly developed RIFLE classification, is associated with increased hospital mortality and resource use. Expand
The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
TLDR
The Surviving Sepsis Campaign was associated with sustained, continuous quality improvement in sepsis care and a reduction in reported hospital mortality rates wasassociated with participation. Expand
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