FAQ

Sex Hormone-Binding Globulin

Known as: sex hormone binding globulin (SHBG), Sex Hormone Binding Globulin, Binding Globulin, Testosterone-Estradiol 
A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2018
05010015019702018

Related topics

Related topics

23 relations
Androgen Binding ProteinCellular MembraneGlycoproteinsLigand Binding
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Sex Hormone-Binding Globulin
physiological aspects
agonists
Liver
Glycoproteins
Testis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Sex hormone-binding globulin and risk of type 2 diabetes.
BACKGROUND Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these… (More)
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Highly Cited
2006
Highly Cited
2006
Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men.
BACKGROUND The metabolic syndrome (MetS), characterized by central obesity, lipid and insulin dysregulation, and hypertension, is… (More)
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Highly Cited
2004
Highly Cited
2004
Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men.
OBJECTIVE In men, hypoandrogenism is associated with features of the metabolic syndrome, but the role of sex hormones in the… (More)
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Highly Cited
2002
Highly Cited
2002
Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies.
BACKGROUND Reproductive and hormonal factors are involved in the etiology of breast cancer, but there are only a few prospective… (More)
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Highly Cited
2000
Highly Cited
2000
Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study.
OBJECTIVE The objective was to examine prospectively the association between low testosterone and sex hormone-binding globulin… (More)
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Highly Cited
2000
Highly Cited
2000
A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition.
The aims of this study were to describe, in relation to date of final menses, the average androgen levels of women in the years… (More)
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Highly Cited
1996
Highly Cited
1996
Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males.
Several aspects of the regulation of androgen secretion and plasma levels in males remain controversial. Among these, we cite the… (More)
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Highly Cited
1996
Highly Cited
1996
Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. MRFIT Research Group. Multiple Risk Factor Intervention Trial.
Few prospective data are available regarding the association of sex hormone-binding globulin (SHBG), testosterone, and the risk… (More)
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Highly Cited
1991
Highly Cited
1991
A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome.
To determine whether hyperinsulinemia can directly reduce serum sex hormone-binding globulin (SHBG) levels in obese women with… (More)
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Highly Cited
1988
Highly Cited
1988
Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin.
Sex hormone-binding globulin (SHBG) production in humans has been thought to be stimulated by estrogens and thyroid hormone and… (More)
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