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A consensus on criteria for cure of acromegaly.
OBJECTIVE The Acromegaly Consensus Group met in April 2009 to revisit the guidelines on criteria for cure as defined in 2000. PARTICIPANTS Participants included 74 neurosurgeons andExpand
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Activation of p53 by MEG3 Non-coding RNA*
MEG3 is a maternally expressed imprinted gene suggested to function as a non-coding RNA. Our previous studies suggest that MEG3 has a function of tumor suppression. The tumor suppressor p53 plays aExpand
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Long-term mortality after transsphenoidal surgery and adjunctive therapy for acromegaly.
To analyze the long term outcome after multimodality therapy for acromegaly, a retrospective review was performed on 162 patients who underwent transsphenoidal surgery at Massachusetts GeneralExpand
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Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant.
BACKGROUND Patients with acromegaly are currently treated with surgery, radiation therapy, and drugs to reduce hypersecretion of growth hormone, but the treatments may be ineffective and have adverseExpand
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Ipilimumab-induced hypophysitis: a detailed longitudinal analysis in a large cohort of patients with metastatic melanoma.
CONTEXT Ipilimumab (Ipi) is approved by the Food and Drug Administration for the treatment of unresectable or metastatic melanoma. Little is known about Ipi-induced hypophysitis (IH), an importantExpand
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Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues
Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. Here we show region-specific variation in MAT adipocyte development, regulation, size, lipidExpand
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Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.
The adipocyte-derived hormone adiponectin promotes metabolic and cardiovascular health. Circulating adiponectin increases in lean states such as caloric restriction (CR), but the reasons for thisExpand
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MEG3 noncoding RNA: a tumor suppressor.
Maternally expressed gene 3 (MEG3) is an imprinted gene belonging to the imprinted DLK1-MEG3 locus located at chromosome 14q32.3 in humans. Its mouse ortholog, Meg3, also known as gene trap locus 2Expand
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Effects of recombinant human IGF-I and oral contraceptive administration on bone density in anorexia nervosa.
Over 90% of women with anorexia nervosa demonstrate osteopenia, and almost 40% demonstrate osteoporosis at one or more skeletal sites. In addition to estrogen deficiency causing an increase in boneExpand
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Expert consensus document: A consensus on the medical treatment of acromegaly
In March 2013, the Acromegaly Consensus Group met to revise and update guidelines for the medical treatment of acromegaly. The meeting comprised experts skilled in the medical management ofExpand
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