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A consensus on criteria for cure of acromegaly.
TLDR
Criteria to define active acromegaly and disease control were agreed, and several significant changes were made to the 2000 guidelines.
Activation of p53 by MEG3 Non-coding RNA*
TLDR
It is found that transfection of expression constructs for MEG3 and its isoforms results in a significant increase in p53 protein levels and dramatically stimulates p 53-dependent transcription from a p53-responsive promoter, supporting the concept that M EG3 functions as a non-coding RNA.
Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist
TLDR
Pegvisomant is an effective medical treatment for acromegaly and of the patients treated for 12 months or more, 87 of 90 (97%) achieved a normal serum IGF-1 concentration.
Osteoporosis prevention, diagnosis, and therapy.
TLDR
Though prevalent in white postmenopausal women, osteoporosis occurs in all populations and at all ages and has significant physical, psychosocial, and financial consequences.
Long-term mortality after transsphenoidal surgery and adjunctive therapy for acromegaly.
TLDR
A retrospective review of patients who underwent transsphenoidal surgery at Massachusetts General Hospital between 1978 and 1996 suggests that the decreased survival previously reported to be associated with acromegaly can be normalized by successful surgical and adjunctive therapy.
Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant.
TLDR
Treatment of patients who have acromegaly with pegvisomant with a growth hormone-receptor antagonist results in a reduction in serum IGF-I concentrations and in clinical improvement.
Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction.
TLDR
It is revealed that both MAT and serum adiponectin increase during cancer therapy in humans, and these observations identify MAT as an endocrine organ that contributes significantly to increased serum adip onectin during CR and perhaps in other adverse states.
Abnormal bone mineral accrual in adolescent girls with anorexia nervosa.
TLDR
Poor bone mineral accrual persists in adolescent girls with AN in contrast to rapid bone accruals in healthy girls, and normalization of bone turnover markers occurs in association with nutritional recovery and an increase in the nutritionally dependent bone trophic factor IGF-I.
Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism.
TLDR
It is concluded that testosterone therapy given to adult men with acquired hypogonadism decreases sc fat and increases lean muscle mass and testosterone therapy reduces bone remodeling and increases trabecular bone density.
Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement.
TLDR
Thirty-two leading endocrinologists, clinicians, and neurosurgeons with specific expertise in the management of ACTH-dependent Cushing's syndrome representing nine countries were chosen to address criteria for cure and remission of this disorder.
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