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Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain
Age-related loss of brain tissue has been inferred from cross-sectional neuroimaging studies, but direct measurements of gray and white matter changes from longitudinal studies are lacking. WeExpand
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Neuropsychological function in schizophrenia. Selective impairment in memory and learning.
Unmedicated schizophrenic patients (according to DSM-III-R criteria) (n = 36) and age-matched normal controls (n = 36), balanced for parental socioeconomic status, were administered a battery ofExpand
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One-year age changes in MRI brain volumes in older adults.
Longitudinal studies indicate that declines in cognition and memory accelerate after age 70 years. The neuroanatomic and neurophysiologic underpinnings of cognitive change are unclear, as there isExpand
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Hearing loss and incident dementia.
OBJECTIVE To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD). DESIGN Prospective study of 639 individuals who underwent audiometric testingExpand
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Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging
We report evidence that computer-based high-dimensional pattern classification of magnetic resonance imaging (MRI) detects patterns of brain structure characterizing mild cognitive impairment (MCI),Expand
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Age differences in the neural systems supporting human allocentric spatial navigation
Age-related declines in spatial navigation are well-known in human and non-human species. Studies in non-human species suggest that alteration in hippocampal and other neural circuitry may underlieExpand
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Hearing loss and cognition in the Baltimore Longitudinal Study of Aging.
OBJECTIVE To determine the relationship between hearing loss and cognitive function as assessed with a standardized neurocognitive battery. We hypothesized a priori that greater hearing loss isExpand
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Longitudinal pattern of regional brain volume change differentiates normal aging from MCI
Background: Neuroimaging measures have potential as surrogate markers of disease through identification of consistent features that occur prior to clinical symptoms. Despite numerous investigations,Expand
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Voxel-Based Morphometry Using the RAVENS Maps: Methods and Validation Using Simulated Longitudinal Atrophy
TLDR
This paper presents an extension and validation of a previously published methodology, referred to as RAVENS, for characterizing regional atrophy in the brain. Expand
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Structural and functional biomarkers of prodromal Alzheimer's disease: A high-dimensional pattern classification study
TLDR
This work builds upon previous studies that reported high sensitivity and specificity in classifying individuals with mild cognitive impairment (MCI), which is often a prodromal phase of Alzheimer's disease (AD), via pattern classification of MRI scans. Expand
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