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The serum transport of steroid hormones.
Publisher Summary This chapter discusses the serum transport of steroid hormones. Steroid hormones are extensively bound to plasma proteins including albumin, corticosteroid binding globulin (CBG),Expand
Genetic Determinants of Serum Testosterone Concentrations in Men
Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's highExpand
Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene.
The liver produces plasma sex hormone-binding globulin (SHBG), which transports sex steroids and regulates their access to tissues. In overweight children and adults, low plasma SHBG levels are aExpand
Hepatocyte Nuclear Factor-4 Controls Transcription from a TATA-less Human Sex Hormone-binding Globulin Gene Promoter*
Hepatocytes are the major source of sex hormone-binding globulin (SHBG), a glycoprotein that transports sex steroids in the blood and regulates their access to target tissues. The human SHBG proximalExpand
Diverse Roles for Sex Hormone-Binding Globulin in Reproduction1
  • G. Hammond
  • Biology, Medicine
  • Biology of reproduction
  • 1 September 2011
Sex hormone-binding globulin (SHBG) transports androgens and estrogens in blood and regulates their access to target tissues. Hepatic production of SHBG fluctuates throughout the life cycle and isExpand
Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action
  • G. Hammond
  • Biology, Medicine
  • The Journal of endocrinology
  • 1 July 2016
Biologically active steroids are transported in the blood by albumin, sex hormone-binding globulin (SHBG), and corticosteroid-binding globulin (CBG). These plasma proteins also regulate theExpand
Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors.
We have isolated and sequenced cDNAs for corticosteroid binding globulin (CBG) prepared from human liver and lung mRNAs. Our results indicate that CBG mRNA is relatively abundant in the liver but isExpand
The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs.
When a sex hormone-binding globulin (SHBG) cDNA was used to screen a human testicular cDNA library, three distinct cDNAs were isolated, one of which corresponds to the human SHBG cDNA sequence andExpand
Crystal structure of human sex hormone‐binding globulin: steroid transport by a laminin G‐like domain
Human sex hormone‐binding globulin (SHBG) transports sex steroids in blood and regulates their access to target tissues. In biological fluids, SHBG exists as a homodimer and each monomer comprisesExpand
A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils.
In human blood, cortisol is transported by a plasma protein known as corticosteroid-binding globulin (CBG). As anticipated from primary structure comparisons of CBG and alpha 1-proteinase inhibitorExpand