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Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.
Many studies have shown cross-sectional (and two small studies, longitudinal) declines in total and/or free testosterone (T) levels, with age, in men. The extent to which decline in T is the resultExpand
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Human growth hormone and human aging.
In humans, both aging and GH deficiency are associated with reduced protein synthesis, decreased lean body and bone mass, and increased percent body fat. In healthy individuals, spontaneous andExpand
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Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men.
Circulating testosterone (T) levels have behavioral and neurological effects in both human and nonhuman species. Both T concentrations and neuropsychological function decrease substantially with ageExpand
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Mitochondria as key components of the stress response
The exquisitely orchestrated adaptive response to stressors that challenge the homeostasis of the cell and organism involves important changes in mitochondrial function. A complex signaling networkExpand
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Free testosterone and risk for Alzheimer disease in older men
Objective: To investigate the relationships between age-associated decreases in endogenous serum total testosterone (T) and a free T index (FTI) in men and the subsequent development of AlzheimerExpand
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Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial.
CONTEXT Hormone administration to elderly individuals can increase lean body mass (LBM) and decrease fat, but interactive effects of growth hormone (GH) and sex steroids and their influence onExpand
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Health behaviors and risk factors in those who use complementary and alternative medicine
BackgroundSurveys have generally found that individuals more likely to use complementary and alternative medicine are female, live in the western United States, are likely to have a health complaint,Expand
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Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-specific antigen as predictors of clinical prostate cancer.
Insulin-like growth factors (IGFs) may play a role in prostate growth, hyperplasia, and malignancy. High plasma IGF-I has been associated with increased prostate cancer risk. In a prospective,Expand
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Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men.
Aging is associated with reduced GH, IGF-I, and sex steroid axis activity and with increased abdominal fat. We employed a randomized, double-masked, placebo-controlled, noncross-over design to studyExpand
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Aging, androgens, and the metabolic syndrome in a longitudinal study of aging.
BACKGROUND Based on Adult Treatment Panel III criteria, we previously reported that the prevalence of the metabolic syndrome (MS) increased with aging; was higher if elevated 2-h plasma postglucoseExpand
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