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Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.
TLDR
Observations of health factor independent, age-related longitudinal decreases in T and free T, resulting in a high frequency of hypogonadal values, suggest that further investigation of T replacement in aged men, perhaps targeted to those with the lowest serum T concentrations, are justified.
Human growth hormone and human aging.
TLDR
It may be justifiable initially to limit use of GH to certain elderly patients such as those suffering from catabolic illnesses, malnourishment, burns, cachexia, etc, but a great deal more research will be necessary to determine whether normalization of GH and IGF-I levels in healthy older persons will lead to improvements in their physical and psychological functional capacity and quality of life.
Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men.
TLDR
A possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men is suggested.
Mitochondria as key components of the stress response
TLDR
Understanding the often reciprocal interplay between stress mediators and mitochondrial function is likely to help identify potential therapeutic targets for many stress and mitochondria-related pathologies.
Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial.
TLDR
GH with or without sex steroids in healthy, aged women and men increased LBM and decreased fat mass and sex steroid + GH increased muscle strength marginally and VO( 2)max.
Free testosterone and risk for Alzheimer disease in older men
TLDR
Calculated free testosterone concentrations were lower in men who developed Alzheimer disease, and this difference occurred before diagnosis, and future research may determine whether higher endogenous free testosterone levels offer protection against a diagnosis of Alzheimer disease in older men.
Health behaviors and risk factors in those who use complementary and alternative medicine
TLDR
It is found that engaging in leisure-time physical activity, having consumed alcohol in one's life but not being a current heavy drinker, and being a former smoker are independently associated with the use of CAM.
Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-specific antigen as predictors of clinical prostate cancer.
TLDR
The data suggest that IGF-II may inhibit both prostate growth and development of prostate cancer, which is inconsistent with increased ascertainment in men with large prostates as the source of greater prostate cancer risk associated with IGF-I.
Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
TLDR
Frail subjects have lower levels of serum IGF-I and DHEA-S and higher levels of IL-6 than do non-frail, age-matched individuals, suggests potential interaction between endocrine and immune/cytokine dysregulation that requires further study in larger cohorts.
Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men.
TLDR
The generally proportionate reductions the authors observed in sc and visceral fat, after 6 months of GH administration in healthy aged men, contrast with the disproportionate reduction of visceral fat reported after a similar period of GH treatment of nonelderly GH deficient men and women.
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