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Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain
MRI scans of 92 nondemented older adults in the Baltimore Longitudinal Study of Aging provide essential information on the rate and regional pattern of age-associated changes against which pathology can be evaluated and suggest slower rates of brain atrophy in individuals who remain medically and cognitively healthy.
Vitamin D-binding protein and vitamin D status of black Americans and white Americans.
Community-dwelling black Americans, as compared with whites, had low levels of total 25-hydroxyvitamin D and vitamin D-binding protein, resulting in similar concentrations of estimated bioavailable 25-Hydroxyv vitamin D.
Hearing loss and incident dementia.
Hearing loss is independently associated with incident all-cause dementia, and whether hearing loss is a marker for early-stage dementia or is actually a modifiable risk factor for dementia deserves further study.
Evaluating replicability of factors in the Revised NEO Personality Inventory: Confirmatory factor analysis versus Procrustes rotation.
Despite the empirical robustness of the 5-factor model of personality, recent confirmatory factor analyses (CFAs) of NEO Personality Inventory (NEO-PI) data suggest they do not fit the hypothesized
One-year age changes in MRI brain volumes in older adults.
Definition of the pattern and rate of longitudinal brain changes will facilitate the detection of pathological brain changes, which may be predictors of dementia, in nondemented older participants in the Baltimore Longitudinal Study of Aging.
AGEMAP: A Gene Expression Database for Aging in Mice
The AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database is presented, which is a resource that catalogs changes in gene expression as a function of age in mice and finds great heterogeneity in the amount of transcriptional changes with age in different tissues.
Hearing loss and cognition in the Baltimore Longitudinal Study of Aging.
Hearing loss is independently associated with lower scores on tests of memory and executive function, and this results were robust to analyses accounting for potential confounders, nonlinear effects of age, and exclusion of individuals with severe hearing loss.
Personality and obesity across the adult life span.
Low Agreeableness and impulsivity-related traits predicted a greater increase in BMI across the adult life span than high Neuroticism and low Conscientiousness, and the facets of these traits related to difficulty with impulse control were associated with weight fluctuations.
Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease
To examine the preclinical onset of cognitive decline, subjects were aligned at the time of initial AD diagnosis and the cognitive course preceding diagnosis found that declines in performance on tests of episodic memory accelerated 7 years before diagnosis.