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STAT4 gene

Known as: SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4, STAT4, Signal Transducer and Activator of Transcription 4 Gene 
This gene is involved in signal transduction and activation of transcription. It plays a role in regulation of T-helper cell differentiation.
National Institutes of Health

Related topics

Related topics

6 relations
Crohn DiseaseHomo sapiensSTAT4 proteinSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Understanding the major risk factors in the beginning and the progression of rheumatoid arthritis: current scenario and future prospects
Rheumatoid arthritis (RA), a chronic progressive inflammatory autoimmune disorder characterized by chronic pain and swelling… 
Review
2013
Review
2013
Entering a new phase of immunogenetics in the idiopathic inflammatory myopathies
Purpose of reviewTo review the progress that has been made in understanding the genetics of the idiopathic inflammatory… 
Highly Cited
2009
Highly Cited
2009
Population differences in SLE susceptibility genes : STAT 4 and BLK , but not PXK , are associated with systemic lupus erythematosus in Hong Kong Chinese
W Yang, P Ng, M Zhao, N Hirankarn, CS Lau, CC Mok, TM Chan, RWS Wong, KW Lee, MY Mok, SN Wong, Y Avihingsanon, TL Lee, MHK Ho… 
2009
2009
Interleukin‐12 is sufficient to promote antigen‐independent interferon‐γ production by CD8 T cells in old mice
Numerous functional defects have been identified in naive T cells from aged mice, including deficiencies in proliferation… 
2006
2006
STAT4 and the proliferation of artery smooth muscle cells in atherosclerosis.
2005
2005
Association analysis of signal transducer and activator of transcription 4 (STAT4) polymorphisms with asthma
AbstractThe signal transducer and activator of transcription 4 (STAT4) on chromosome 2q32.2-q32.3 is known to be essential for… 
2001
2001
A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin.
Underlying viral infections can heighten sensitivity and worsen cytokine-mediated disease following secondary inflammatory… 
Highly Cited
2000
Highly Cited
2000
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
We used signal transducer and activator of transcription 4 (STAT4) and STAT6 gene knockout (-/-) mice as recipients of fully… 
1999
1999
Upregulation of integrin alpha6/beta1 and chemokine receptor CCR1 by interleukin-12 promotes the migration of human type 1 helper T cells.
CD4(+) T helper 1 (Th1) cells and Th2 cells are distinguished based on the pattern of cytokines they are able to produce… 
1997
1997
cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.
Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of… 
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