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JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
TLDR
The results support the hypothesis that JAK2 is the kinase that couples EPO binding to tyrosine phosphorylation and mitogenesis. Expand
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
TLDR
A new Jak family kinase is described, and it is demonstrated that Jak-3, and to a lesser extent Jak-1, are tyrosine phosphorylated and Jak- 3 is activated in the responses to interleukin-2 and interLEukin–4 in T cells and myeloid cells. Expand
Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, Epstein–Barr virus, and clonality are important predictors of disease progression and regression
TLDR
The objective of this study was to identify factors predictive of relapse and survival in Patients with RA‐LPD, and spontaneous regression in patients with RA-LPD treated with MTX (MTX‐L PD). Expand
SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit.
TLDR
It is demonstrated that suppressor of cytokine signaling-3 (SOCS-3), expressed at high levels in Th2 cells, plays an inhibitory role in STAT4-mediated IL-12 signaling by binding to the STAT4 docking site in IL- 12Rbeta2, thus raising a possibility that SOCS- 3 may play a role in regulation of Th differentiation. Expand
Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.
TLDR
The results suggest that the carboxyl-terminal region of EpoR may play a crucial role in activation of MAP kinases through the Ras signaling pathway which may be activated by tyrosine phosphorylation of Shc and its association with Grb2. Expand
Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
TLDR
It is demonstrated that Lyn, a Src family tyrosine kinase, physically associates with the EpoR in Epo-dependent hematopoietic cell lines, 32D/EpoR-Wt and F36E, and indicates that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpOR. Expand
Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.
TLDR
Two mutants of the EpoR that lacked 108 or 146 amino acids at their carboxyl termini were generated, and an internally deleted mutant that lacked 20 amino acids in a region of sequence homology with the IL-2 receptor beta chain was constructed. Expand
BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells
TLDR
BCL6 overexpression was found to inhibit the increase in ROS levels and apoptosis in response to etoposide and other chemotherapeutic reagents, raising the possibility that deregulated expression of BCL6 may endow lymphoma cells with resistance to chemotherAPEutic re agents, most likely by enhancing the antioxidant defense systems. Expand
Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites.
TLDR
HCP binds the tyrosine phosphorylated Epo receptor through the amino-terminal src-homology 2 (SH2) domain of HCP, which supports the concept that, after Epo stimulation, phosphorylation of EpoR provides a docking site for HCP in the receptor complex. Expand
Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
TLDR
It is demonstrated that Lyn, a Src family tyrosine kinase, physically associates with the EpoR in Epo-dependent hematopoietic cell lines, 32D/EpoR-Wt and F36E, and indicates that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpOR. Expand
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