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Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, Epstein–Barr virus, and clonality are important predictors of disease progression and regression
Patients with rheumatoid arthritis (RA) may develop lymphoproliferative disorders (RA‐LPD). Immunosuppressive states due to methotrexate (MTX) and Epstein–Barr virus (EBV) reactivation have beenExpand
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SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit.
IL-12 promotes the proliferation of T cells as well as NK cells and plays a critical role in induction of the Th1 differentiation. IL-12 mediates its biological activities through activation of theExpand
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Social organization and caste formation in three additional parasitic flatworm species
There are many examples of reproductive division of labor in terrestrial animal societies, but only a few have been reported in aquatic systems. A recent study discovered social organization of aExpand
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Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.
The erythropoietin receptor (EpoR) belongs to the cytokine receptor family, members of which lack a tyrosine kinase domain. Recent studies, however, have shown that a cytoplasmic tyrosine kinase,Expand
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Molecular phylogenetics reveals differential divergence of coastal snails separated by the Isthmus of Panama.
We used 20 species of coastal marine snails in the genus Cerithidea and Cerithium collected along the Pacific and Atlantic coasts of Central America to investigate the role of the rise of the IsthmusExpand
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The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells.
IL-12 activates STAT4 by inducing tyrosine phosphorylation, homo-dimerization, and nuclear translocation in NK cells and thereby stimulates proliferation and activation of these cells. TheExpand
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Introduced cryptic species of parasites exhibit different invasion pathways
Sometimes infectious agents invade and become established in new geographic regions. Others may be introduced yet never become established because of the absence of suitable hosts in the new region.Expand
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Molecular genetic approaches to elucidate the ecological and evolutionary issues associated with biological invasions
  • O. Miura
  • Biology
  • Ecological Research
  • 14 June 2007
Biological invasions may cause serious damage to the native environments and threaten the native biodiversity. Molecular genetic approaches have been found to be powerful tools for investigating theExpand
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Organization of the human alpha 2-plasmin inhibitor gene.
We have isolated overlapping phage genomic clones covering an area of 26 kilobases that encodes the human alpha 2-plasmin inhibitor. The alpha 2-plasmin inhibitor gene contains 10 exons and 9 intronsExpand
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Soil disturbance regime in relation to micro-scale landforms and its effects on vegetation structure in a hilly area in Japan
To clarify vegetation-landform relationships, we examined the soil disturbance regime in relation to micro-scale landforms and its effects on vegetation structure in a mixed temperate forest in aExpand
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