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Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a
In this 5-year extension study, tocilizumab demonstrated sustained long-term efficacy and a generally good safety profile. Expand
High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis
ELISA detection of antibodies to citrullinated antigens, especially a second generation anti‐CCP, showed higher discriminative ability than other assays, including RF, and would be useful to aid the diagnosis of RA in clinical practice. Expand
Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese
Objective: The primary aim of this study was to investigate the association of polymorphisms of TRAF1-C5, a newly identified rheumatoid arthritis (RA) risk locus in Caucasians, with susceptibility toExpand
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis.
The results showed that PADI4 is mainly distributed in cells of various haematopoietic lineages and expressed at high levels in the inflamed RA synovium and the notion that citrullinated fibrin is a potential antigen of RA autoimmunity is supported. Expand
Safety of tacrolimus, an immunosuppressive agent, in the treatment of rheumatoid arthritis in elderly patients.
In elderly patients with insufficient response to DMARD therapy, tacrolimus at 1.5-3.0 mg/day is safe and well-tolerated and provides clinical benefit. Expand
Possible involvement of Epstein-Barr virus in polyclonal B cell activation in Sjögren's syndrome.
Serum levels of anti-viral capsid antigen antibodies of both the IgG and the IgM class were significantly elevated in patients with Sjögren's syndrome and an EBV-specific regulatory mechanism was impaired in these patients. Expand
Citrullination of fibronectin in rheumatoid arthritis synovial tissue.
The results suggest that the citrullination of Fn is a specific event for RA synovium, although others have detectedcitrullinated total proteins in inflamed synovial tissue of RA and non-RA patients. Expand
Therapeutic selective adsorption of anti-DNA antibody using dextran sulfate cellulose column (Selesorb) for the treatment of systemic lupus erythematosus.
Clinical application of the Selesorb system to SLE patients with high titers of anti-DNA antibody showed improvement of proteinurea, arthralgia, rash, lymphocytopenia, etc., with the concurrent use of steroid and/or immnosuppressant. Expand
Spontaneous production of Epstein-Barr virus by B lymphoblastoid cell lines obtained from patients with Sjögren's syndrome. Possible involvement of a novel strain of Epstein-Barr virus in disease
Spontaneous, massive production of EBV by B cell lines is unique to SS, and may contribute to the polyclonal B cell activation seen in this disease. Expand
Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids
Background: Anti-citrullinated protein antibodies (ACPA) are specifically and frequently detected in sera of patients with rheumatoid arthritis (RA). Citrullinated fibrin or fibrinogen is a candidateExpand