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Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled
TLDR
Tocilizumab monotherapy was generally well tolerated and provided radiographic benefit in patients with RA and improved signs and symptoms. Expand
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial.
TLDR
Treatment with MRA was generally well tolerated and significantly reduced the disease activity of RA, and the adverse events were not dose dependent. Expand
Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular
TLDR
Tocilizumab monotherapy was well tolerated and provided an excellent clinical benefit in active RA patients with an inadequate response to low dose MTX. Expand
Chemokines Regulate IL-6 and IL-8 Production by Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis1
TLDR
The results indicate that the chemokines not only play a role in inflammatory cell migration, but are also involved in the activation of FLS in RA synovium, possibly in an autocrine or paracrine manner. Expand
Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a
TLDR
In this 5-year extension study, tocilizumab demonstrated sustained long-term efficacy and a generally good safety profile. Expand
SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit.
TLDR
It is demonstrated that suppressor of cytokine signaling-3 (SOCS-3), expressed at high levels in Th2 cells, plays an inhibitory role in STAT4-mediated IL-12 signaling by binding to the STAT4 docking site in IL- 12Rbeta2, thus raising a possibility that SOCS- 3 may play a role in regulation of Th differentiation. Expand
Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
TLDR
Bcl6 is essential for the differentiation of GC B cells, and its products are expressed highly in germinal center (GC) B cells. Expand
Revised Japanese criteria for Sjögren’s syndrome (1999): availability and validity
TLDR
To evaluate the validity of the revised Japanese criteria, the records of 900 patients, including SS patients and non-SS controls, from 54 clinical centers were registered and analyzed and the accuracy of the criteria was found to have 96.5% accuracy. Expand
Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
TLDR
It is demonstrated that Lyn, a Src family tyrosine kinase, physically associates with the EpoR in Epo-dependent hematopoietic cell lines, 32D/EpoR-Wt and F36E, and indicates that Lyn may play a role in activation of the Jak2/Stat5 and other signaling pathways by the EpOR. Expand
Amelioration of Collagen-Induced Arthritis by Blockade of Inducible Costimulator-B7 Homologous Protein Costimulation1
TLDR
A beneficial effect of the B7h blockade on CIA is shown through anti-inflammatory actions and inhibition of both Th1- and Th2-mediated immune responses, suggesting that the ICOS-B7h interaction plays an important role in the pathogenesis of CIA and thus the blockade of this pathway may be beneficial for the treatment of human rheumatoid arthritis. Expand
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