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STAT4 protein

Known as: Transcription Factor, STAT4, STAT4 Transcription Factor, STAT4 Transcription Factor [Chemical/Ingredient] 
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-12 in T-LYMPHOCYTES. Stat4 is an important… Expand
National Institutes of Health

Related topics

Related topics

21 relations
Crohn DiseaseDNA-Binding ProteinsGenes, RegulatorIL12 Signaling Pathway
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Papers overview

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Highly Cited
2007
Highly Cited
2007
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
BACKGROUND Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease… Expand
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Highly Cited
2007
Highly Cited
2007
Stat3 and Stat4 direct development of IL-17-secreting Th cells.
IL-17-secreting CD4(+) T cells are critically involved in inflammatory immune responses. Development of these cells is promoted… Expand
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Highly Cited
2005
Highly Cited
2005
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control… Expand
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Review
2004
Review
2004
Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.
Produced in response to a variety of pathogenic organisms, interleukin (IL)-12 and IL-23 are key immunoregulatory cytokines that… Expand
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Highly Cited
2002
Highly Cited
2002
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection.
Interferons (IFNs) are essential for host defense. Although the antiviral effects of the type 1 IFNs IFN-alpha and IFN-beta (IFN… Expand
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Highly Cited
2000
Highly Cited
2000
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which… Expand
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Review
2000
Review
2000
The biology of Stat4 and Stat6
IL-4 and IL-12 are cytokines that are important regulators of the proliferation, differentiation and functional capacity of… Expand
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Highly Cited
1996
Highly Cited
1996
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
INTERACTIONS between cytokine and receptor lead to the activation of multiple signalling molecules, including the family of… Expand
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Highly Cited
1996
Highly Cited
1996
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
SIGNAL transducers and activators of transcription (STATs) are activated by tyrosine phosphorylation in response to cytokines and… Expand
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Highly Cited
1995
Highly Cited
1995
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
Interleukin 12 (IL-12) initiates the differentiation of naive CD4+ T cells to T helper type 1 (Th1) cells critical for resistance… Expand
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