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STAT4 protein
Known as:
Transcription Factor, STAT4
, STAT4 Transcription Factor
, STAT4 Transcription Factor [Chemical/Ingredient]
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A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-12 in T-LYMPHOCYTES. Stat4 is an important…
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National Institutes of Health
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Related topics
Related topics
21 relations
Crohn Disease
DNA-Binding Proteins
Genes, Regulator
IL12 Signaling Pathway
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Natural killer cell functional dichotomy: a feature of chronic viral hepatitis?
M. Mondelli
,
B. Oliviero
,
D. Mele
,
S. Mantovani
,
Chiara Gazzabin
,
S. Varchetta
Front. Immun.
2012
Corpus ID: 18543304
Natural killer (NK) cells are involved in innate immune responses to viral infections either via direct cytotoxicity which…
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Highly Cited
2009
Highly Cited
2009
Population differences in SLE susceptibility genes : STAT 4 and BLK , but not PXK , are associated with systemic lupus erythematosus in Hong Kong Chinese
JT Elder
2009
Corpus ID: 22026222
W Yang, P Ng, M Zhao, N Hirankarn, CS Lau, CC Mok, TM Chan, RWS Wong, KW Lee, MY Mok, SN Wong, Y Avihingsanon, TL Lee, MHK Ho…
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Highly Cited
2005
Highly Cited
2005
Increased sensitivity to interferon-α in psoriatic T cells
K. W. Eriksen
,
P. Lovato
,
+4 authors
N. Ødum
2005
Corpus ID: 72149588
Psoriasis is a chronic inflammatory skin disease characterized by abnormal epidermal proliferation. Several studies have shown…
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Review
2005
Review
2005
Therapeutic Potential of Oligonucleotides Expressing Immunosuppressive TTAGGG Motifs
D. Klinman
,
I. Gursel
,
S. Klaschik
,
Li Dong
,
D. Currie
,
H. Shirota
Annals of the New York Academy of Sciences
2005
Corpus ID: 8142725
Synthetic oligodeoxynucleotides (ODNs) expressing immunosuppressive TTAGGG motifs downregulate the production of proinflammatory…
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Highly Cited
2000
Highly Cited
2000
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
Koji Kishimoto
,
V. Dong
,
+9 authors
M. Sayegh
Journal of Clinical Investigation
2000
Corpus ID: 8171319
We used signal transducer and activator of transcription 4 (STAT4) and STAT6 gene knockout (-/-) mice as recipients of fully…
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Highly Cited
2000
Highly Cited
2000
Increased Susceptibility of Stat4-Deficient and Enhanced Resistance in Stat6-Deficient Mice to Infection with Trypanosoma cruzi1
R. Tarleton
,
M. Grusby
,
Lei Zhang
Journal of Immunology
2000
Corpus ID: 13484617
Although Th1-type responses tend to be associated with resistance to Trypanosoma cruzi infection, mixed Th1 and Th2 cytokine…
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Highly Cited
1999
Highly Cited
1999
STAT‐4 mediated IL‐12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
L. Stamm
,
A. Satoskar
,
Sudip K. Ghosh
,
J. David
,
A. Satoskar
European Journal of Immunology
1999
Corpus ID: 23613009
Recent studies have demonstrated that two IL‐12 signaling pathways, a STAT 4 – dependent and STAT4 – independent, are involved in…
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Highly Cited
1999
Highly Cited
1999
Mutations of the IL-12 receptor beta2 chain gene in atopic subjects.
E. Matsui
,
H. Kaneko
,
+5 authors
Naomi Kondo
Biochemical and Biophysical Research…
1999
Corpus ID: 44971835
Interleukin-12(IL-12) promotes cell-mediated Th1 responses and production of IFN-gamma that downregulates IgE production. The…
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Highly Cited
1996
Highly Cited
1996
Lack of IL-12 signaling in human allergen-specific Th2 cells.
C. Hilkens
,
Gerald Messer
,
K. Tesselaar
,
A. G. I. V. Rietschoten
,
M. Kapsenberg
,
E. Wierenga
Journal of Immunology
1996
Corpus ID: 25115672
IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells…
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Review
1996
Review
1996
Regulation of interleukin-12 signalling during T helper phenotype development.
N. G. Jacobson
,
S. Szabo
,
M. L. Güler
,
J. Gorham
,
K. Murphy
Advances in Experimental Medicine and Biology
1996
Corpus ID: 7883328
The experiments described above have allowed us to define the molecular events in IL-12 signalling. Within minutes after IL-12…
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