FAQ

STAT4 protein

Known as: Transcription Factor, STAT4, STAT4 Transcription Factor, STAT4 Transcription Factor [Chemical/Ingredient] 
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-12 in T-LYMPHOCYTES. Stat4 is an important… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2018
020406019942018

Related topics

Related topics

22 relations
Crohn DiseaseDNA-Binding ProteinsGenes, RegulatorIn Blood
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
STAT4 protein
Signal Transduction
physiological aspects
agonists
Crohn Disease
dna binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation.
Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells… (More)
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Highly Cited
2009
Highly Cited
2009
Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose
CD4(+) T cells producing interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) are reported in chronic infections. However, the… (More)
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Highly Cited
2009
Highly Cited
2009
Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.
Increased IFN-alpha signaling is a primary pathogenic factor in systemic lupus erythematosus (SLE). STAT4 is a transcription… (More)
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Highly Cited
2007
Highly Cited
2007
STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.
BACKGROUND Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease… (More)
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Highly Cited
2007
Highly Cited
2007
Association of STAT4 with rheumatoid arthritis in the Korean population.
A recent study in the North American White population has documented the association of a common STAT4 haplotype (tagged by… (More)
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Highly Cited
2003
Highly Cited
2003
Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury.
Recent data support a modulatory role for CD4 T cells in experimental renal ischemia-reperfusion injury (IRI). CD4 T cells can… (More)
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Highly Cited
2002
Highly Cited
2002
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection.
Interferons (IFNs) are essential for host defense. Although the antiviral effects of the type 1 IFNs IFN-alpha and IFN-beta (IFN… (More)
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Highly Cited
2000
Highly Cited
2000
Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4.
Interleukin (IL)-12 plays a critical role in modulating the activities of natural killer (NK) cells and T lymphocytes. In animal… (More)
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Highly Cited
1996
Highly Cited
1996
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice.
Interactions between cytokine and receptor lead to the activation of multiple signalling molecules, including the family of… (More)
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Highly Cited
1995
Highly Cited
1995
Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
Interleukin 12 (IL-12) is an important immunoregulatory cytokine whose receptor is a member of the hematopoietin receptor… (More)
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