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STAT4 protein

Known as: Transcription Factor, STAT4, STAT4 Transcription Factor, STAT4 Transcription Factor [Chemical/Ingredient] 
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-12 in T-LYMPHOCYTES. Stat4 is an important… 
National Institutes of Health

Related topics

Related topics

21 relations
Crohn DiseaseDNA-Binding ProteinsGenes, RegulatorIL12 Signaling Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Population differences in SLE susceptibility genes : STAT 4 and BLK , but not PXK , are associated with systemic lupus erythematosus in Hong Kong Chinese
W Yang, P Ng, M Zhao, N Hirankarn, CS Lau, CC Mok, TM Chan, RWS Wong, KW Lee, MY Mok, SN Wong, Y Avihingsanon, TL Lee, MHK Ho… 
Highly Cited
2005
Highly Cited
2005
Increased sensitivity to interferon-α in psoriatic T cells
Psoriasis is a chronic inflammatory skin disease characterized by abnormal epidermal proliferation. Several studies have shown… 
Highly Cited
2002
Highly Cited
2002
The human perforin gene is a direct target of STAT4 activated by IL-12 in NK cells.
Highly Cited
2000
Highly Cited
2000
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo.
We used signal transducer and activator of transcription 4 (STAT4) and STAT6 gene knockout (-/-) mice as recipients of fully… 
Highly Cited
2000
Highly Cited
2000
Increased Susceptibility of Stat4-Deficient and Enhanced Resistance in Stat6-Deficient Mice to Infection with Trypanosoma cruzi1
Although Th1-type responses tend to be associated with resistance to Trypanosoma cruzi infection, mixed Th1 and Th2 cytokine… 
Review
2000
Review
2000
Molecular aspects of T-cell differentiation.
Differentiated T helper 1 (Th1) and T helper 2 (Th2) T-cells show striking differences in their patterns of cytokine expression… 
Highly Cited
2000
Highly Cited
2000
Impairment of STAT Activation by IL-12 in a Patient with Atypical Mycobacterial and Staphylococcal Infections1
IL-12 plays a pivotal role in the stimulation of immune responses against intracellular infections. This role is manifested in… 
Highly Cited
1999
Highly Cited
1999
STAT‐4 mediated IL‐12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
Recent studies have demonstrated that two IL‐12 signaling pathways, a STAT 4 – dependent and STAT4 – independent, are involved in… 
Highly Cited
1999
Highly Cited
1999
Mutations of the IL-12 receptor beta2 chain gene in atopic subjects.
Interleukin-12(IL-12) promotes cell-mediated Th1 responses and production of IFN-gamma that downregulates IgE production. The… 
Highly Cited
1996
Highly Cited
1996
Lack of IL-12 signaling in human allergen-specific Th2 cells.
IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells… 
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