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IL12 Signaling Pathway

Known as: IL12 and Stat4 Dependent Signaling Pathway in Th1 Development 
Interleukin-12 (IL-12) promotes cell-mediated immunity by inducing Th1 cell differentiation and activation of both T cells and NK cells. Dendritic… 
National Institutes of Health

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CCR5 protein, humanCCR5 wt AlleleCD247 wt AlleleCD3D protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
TriCurin, a synergistic formulation of curcumin, resveratrol, and epicatechin gallate, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors
Our earlier studies reported a unique potentiated combination (TriCurin) of curcumin (C) with two other polyphenols. The TriCurin… 
2018
2018
Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+ T cells
ABSTRACT Interleukin-12 (IL12) (p35/p40 complex) is a heterodimeric cytokine with potent anti-tumor activity. However, its short… 
2014
2014
Induction of Wnt-Inducible Signaling Protein-1 Correlates with Invasive Breast Cancer Oncogenesis and Reduced Type 1 Cell-Mediated Cytotoxic Immunity: A Retrospective Study
  • D. Klinke
  • PLoS Comput. Biol.
  • 2014
  • Corpus ID: 449269
Innate and type 1 cell-mediated cytotoxic immunity function as important extracellular control mechanisms that maintain cellular… 
2014
2014
Transcriptome Analysis on the Inflammatory Cell Infiltration of Nonalcoholic Steatohepatitis in Bama Minipigs Induced by a Long-Term High-Fat, High-Sucrose Diet
Long-term adherence to a high-fat, high-calorie diet influences human health and causes obesity, metabolic syndrome and… 
2012
2012
Cryptococcal osteomyelitis in a child with a novel compound mutation of the IL12RB1 gene.
The IL-12p40/IL-12Rbeta1 and IFN-gammaR1/IFN-gammaR2/STAT1 signaling pathways are important for clearing intracellular bacteria… 
2007
2007
Immunogene therapy of recurrent glioblastoma multiforme with a liposomally encapsulated replication-incompetent Semliki forest virus vector carrying the human interleukin-12 gene — a phase I/II…
SummaryGlioblastoma multiforme (GBM) is an incurable brain tumor resistant to standard treatment modalities such as surgery… 
2006
2006
PPARγ antagonists reverse the inhibition of neural antigen-specific Th1 response and experimental allergic encephalomyelitis by Ciglitazone and 15-Deoxy-Δ12,14-Prostaglandin J2
2005
2005
Regulation of T cell-dependent and-independent IL-12 production by the three Th 2-type cytokines lL-1 O , lL-6 , and IL-4
The production of IL-12 by macrophages/ dendritic cells (M4ilDC) is mediated either by a T celldependent pathway that is induced… 
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