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Background: Leishmaniasis is caused by parasitic protozoa of the genus Leishmania which is an obligate intracellular parasite in… Expand Our earlier studies reported a unique potentiated combination (TriCurin) of curcumin (C) with two other polyphenols. The TriCurin… Expand ABSTRACT Interleukin-12 (IL12) (p35/p40 complex) is a heterodimeric cytokine with potent anti-tumor activity. However, its short… Expand Innate and type 1 cell-mediated cytotoxic immunity function as important extracellular control mechanisms that maintain cellular… Expand Long-term adherence to a high-fat, high-calorie diet influences human health and causes obesity, metabolic syndrome and… Expand The IL-12p40/IL-12Rbeta1 and IFN-gammaR1/IFN-gammaR2/STAT1 signaling pathways are important for clearing intracellular bacteria… Expand Despite recent progress, the pathogenic mechanisms governing PBC development, treatment response and outcome remain unknown. This… Expand SummaryGlioblastoma multiforme (GBM) is an incurable brain tumor resistant to standard treatment modalities such as surgery… Expand Peroxisome proliferator-activated receptor-gamma is a nuclear receptor transcription factor that regulates cell growth… Expand The production of IL-12 by macrophages/ dendritic cells (M4ilDC) is mediated either by a T celldependent pathway that is induced… Expand