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Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
Bcl6 is essential for the differentiation of GC B cells, and its products are expressed highly in germinal center (GC) B cells. Expand
Plasma Levels of Endothelial Cell Protein C Receptor Are Elevated in Patients With Sepsis and Systemic Lupus Erythematosus : Lack of Correlation With Thrombomodulin Suggests Involvement of Different
2249, and Ro44-4753, respectively. These synthetic retinoids were kindly provided by F. Hoffman-La Roche, Ltd (Basel, Switzerland). Our experiments also showed that the incubation of NB4 cells withExpand
Organization of the human alpha 2-plasmin inhibitor gene.
The position of the 7th intron of the alpha 2-plasmin inhibitor gene aligns precisely with that of the second introns of the genes for rat angiotensinogen and human alpha 1-antitrypsin genes and is misaligned by only one nucleotide with thatof the third intronof antithrombin III, suggesting that thealpha 2- Plasmin inhibitors gene originates from the common ancestor of these serine protease inhibitors. Expand
Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes in primary lymphoid malignancies.
It is now evident that the cell cycle machinery has a variety of elements negatively regulating cell cycle progression. However, among these negative regulators in cell cycle control, only 4 haveExpand
Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies.
The deletion analyses strongly suggest that the p16 gene is a tumor-suppressor gene located in chromosome 9p21 that is involved in development of human lymphoid tumors. Expand
Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias.
Observations suggest that a gene located at 3q27 is involved in the translocation and that its deregulation plays a role in the malignant transformation of B cells. Expand
Determination of plasma tissue factor antigen and its clinical significance
Ulacentrifugation and immunoblot analysis indicated that human plasma and urine contained 50 000g sedimentable and non‐sedimentable forms of TF, both of which were detected by the ELISA method. Expand
Human genes for complement components C1r and C1s in a close tail-to-tail arrangement.
DNA blotting and sequencing analyses of genomic DNA and of an isolated genomic DNA clone clearly showed that the human genes for C1r and C1s are closely located in a "tail-to-tail" arrangement at a distance of about 9.5 kilobases. Expand
The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene.
The cloned murine BCL6 (mBCL6) cDNA from the muscle cDNA library was 95% identical to that of hBCL 6, indicating that the BCL 6 gene is well conserved between humans and mice. Expand
Identification of negative regulatory regions within the first exon and intron of the BCL6 gene
Two regions in the BCL6 gene are identified, ES and IS, which are located within the first exon between nucleotides +472 and +543 and both had a silencer activity. Expand