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SLC7A5 wt Allele

Known as: CD98, MPE16, E16 
Human SLC7A5 wild-type allele is located in the vicinity of 16q24.3 and is approximately 39 kb in length. This allele, which encodes large neutral… 
National Institutes of Health

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6 relations
16q24.3Homo sapiensIonophore activityLigand Binding

Papers overview

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2018
2018
Co-targeting intracellular pH and essential amino acid uptake cooperates to induce cell death of T-ALL/LL cells
Abstract Cancer cells reprogram their metabolism to optimize their growth and proliferation in the host microenvironment. For… 
2015
2015
LAT1 targeted delivery of methionine based imaging probe derived from M(III) metal ions for early diagnosis of proliferating tumours using molecular imaging modalities.
We investigated the potential of DTPA-bis(Methionine), a target specific amino acid based probe for detection of L-type amino… 
2012
2012
Preclinical characterization of 18F-D-FPHCys, a new amino acid-based PET tracer
PurposeThe imaging potential of a new 18F-labelled methionine derivative, S-(3-[18F]fluoropropyl)-d-homocysteine (18F-D-FPHCys… 
2011
2011
BPA uptake does not correlate with LAT1 and Ki67 expressions in tumor samples (results of EORTC trial 11001).
2007
2007
Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan
Objectives Melphalan is widely used in the treatment of multiple myeloma. Pharmacokinetics of this alkylating drug shows high… 
2004
2004
SPECT and PET Amino Acid Tracer Influx via System L ( h 4 F 2 hc-h LAT 1 ) and Its Transstimulation
System L amino acid transport is increased in various types of cancer. The tracer 123I-2-iodotyrosine (2IT), which is accumulated… 
Highly Cited
2003
Highly Cited
2003
Asymmetry of glutamine transporters in cultured neural cells
2003
2003
Characterization of 3-[125I]iodo-alpha-methyl-L-tyrosine transport via human L-type amino acid transporter 1.
1999
1999
Cutting edge: primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid…
The CD98 light chain (CD98LC) was copurified from HeLa S3 cells by an affinity chromatography using a mAb specific for the fusion… 
1999
1999
Expression of E16/CD98LC/hLAT1 is responsive to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin
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