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SLC7A5 wt Allele

Known as: CD98, MPE16, E16 
Human SLC7A5 wild-type allele is located in the vicinity of 16q24.3 and is approximately 39 kb in length. This allele, which encodes large neutral… 
National Institutes of Health

Related topics

Related topics

6 relations
16q24.3Homo sapiensIonophore activityLigand Binding

Papers overview

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Highly Cited
2018
Highly Cited
2018
The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model
The L-type amino acid transporter 1 (LAT1/SLC7A5) transports essential amino acids across the plasma membrane. While LAT1 is… 
Highly Cited
2015
Highly Cited
2015
Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2
The efficacy of boron neutron capture therapy relies on the selective delivery of boron carriers to malignant cells. p… 
Highly Cited
2014
Highly Cited
2014
Targeting glutamine transport to suppress melanoma cell growth
Amino acids, especially leucine and glutamine, are important for tumor cell growth, survival and metabolism. A range of different… 
Highly Cited
2011
Highly Cited
2011
Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.
L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate… 
Highly Cited
2008
Highly Cited
2008
l‐type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms
The significance of l‐type amino acid transporter (LAT) 1 expression remains unclear in the metastatic process of human neoplasms… 
Highly Cited
2008
Highly Cited
2008
The methylmercury‐l‐cysteine conjugate is a substrate for the L‐type large neutral amino acid transporter
Methylmercury (MeHg) is a potent neurotoxin. The mechanism(s) that governs MeHg transport across the blood‐brain barrier and… 
Review
2000
Review
2000
Surface Antigen CD98(4F2): Not a Single Membrane Protein, But a Family of Proteins with Multiple Functions
CD98(4F2) belongs to a group of approximately two hundred proteins at the surface of leukocytes that are thought to be important… 
Highly Cited
2000
Highly Cited
2000
The 4F2hc/LAT1 complex transports l-DOPA across the blood–brain barrier
Highly Cited
1999
Highly Cited
1999
Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function.
We report here on the cloning and functional characterization of human LAT1, a subunit of the amino acid transport system L. The… 
Highly Cited
1999
Highly Cited
1999
LAT2, a New Basolateral 4F2hc/CD98-associated Amino Acid Transporter of Kidney and Intestine*
Glycoprotein-associated amino acid transporters (gpaAT) are permease-related proteins that require heterodimerization to express… 
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