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Cloning and characterization of two human polyspecific organic cation transporters.
Cl cloning and characterization of two homologous transporters from man (hOCT1 and hOCT2) displaying approximately 80% amino acid identity to rOCT 1 and rO CT2 are reported, respectively.
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.
NDRG1 and NDRG2 are identified as physiological substrates for SGK1, and it is demonstrated that phosphorylation of N DRG1 by SGK 1 primes it for phosphorylated by GSK3.
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells.
Rat MCT4 was identified as the major isoform of white muscle cells, mediating lactate efflux out of glycolytically active myocytes and was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid.
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
- F. Lang, C. Böhmer, M. Palmada, G. Seebohm, N. Strutz‐Seebohm, V. Vallon
- BiologyPhysiological reviews
- 1 October 2006
The serum- and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and under genomic control by cell stress and hormones, and may play an active role in a multitude of pathophysiological conditions.
Na+-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion
The data indicate that SGLT1 is pivotal for intestinal mass absorption of d-glucose, triggers the glucose-induced secretion of GIP and GLP-1, and 3) triggers the upregulation of GLUT2.
Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.
It is shown that hOCT2 message and protein are expressed in neurons of the cerebral cortex and in various subcortical nuclei and that amantadine does not interact with the expressed human Na+/Cl- dopamine cotransporter.
Mechanisms and Significance of Cell Volume Regulation
- F. Lang
- BiologyJournal of the American College of Nutrition
- 9 October 2006
Cell volume regulation following cell shrinkage involves accumulation of ions through activation of Na+,K+,2Cl− cotransport, Na+/H+ exchange in parallel to Cl−/HCO3− exchange, or Na+ channels, and alterations of cell volume participate in the machinery regulating cell proliferation and apoptotic cell death.
Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
Inhibition of Asm as a new treatment strategy for cystic fibrosis is suggested because it shows that ceramide age-dependently accumulates in the respiratory tract of uninfected Cftr-deficient mice and prevents all pathological findings, including susceptibility to infection.
Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus
factors1. Mutations in the connexin26 gene (GJB2), located on 13q12, are responsible for non-syndromic recessive and dominant forms of deafness2–4. Connexin-31 and connexin-32 have also been…
Function and structure of heterodimeric amino acid transporters.
Results highlight complex interactions between the different subunits of heterodimeric amino acid transporters and suggest that despite high grades of homology, the interactions between rbAT and 4F2hc and their respective partners may be different.