• Publications
  • Influence
Cloning and characterization of two human polyspecific organic cation transporters.
TLDR
Cl cloning and characterization of two homologous transporters from man (hOCT1 and hOCT2) displaying approximately 80% amino acid identity to rOCT 1 and rO CT2 are reported, respectively. Expand
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.
TLDR
NDRG1 and NDRG2 are identified as physiological substrates for SGK1, and it is demonstrated that phosphorylation of N DRG1 by SGK 1 primes it for phosphorylated by GSK3. Expand
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
TLDR
The serum- and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and under genomic control by cell stress and hormones, and may play an active role in a multitude of pathophysiological conditions. Expand
Na+-d-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion
TLDR
The data indicate that SGLT1 is pivotal for intestinal mass absorption of d-glucose, triggers the glucose-induced secretion of GIP and GLP-1, and 3) triggers the upregulation of GLUT2. Expand
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells.
TLDR
Rat MCT4 was identified as the major isoform of white muscle cells, mediating lactate efflux out of glycolytically active myocytes and was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid. Expand
Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.
TLDR
It is shown that hOCT2 message and protein are expressed in neurons of the cerebral cortex and in various subcortical nuclei and that amantadine does not interact with the expressed human Na+/Cl- dopamine cotransporter. Expand
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells.
TLDR
Rat MCT4 was identified as the major isoform of white muscle cells, mediating lactate efflux out of glycolytically active myocytes and was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid. Expand
Mechanisms and Significance of Cell Volume Regulation
  • F. Lang
  • Chemistry, Medicine
  • Journal of the American College of Nutrition
  • 9 October 2006
TLDR
Cell volume regulation following cell shrinkage involves accumulation of ions through activation of Na+,K+,2Cl− cotransport, Na+/H+ exchange in parallel to Cl−/HCO3− exchange, or Na+ channels, and alterations of cell volume participate in the machinery regulating cell proliferation and apoptotic cell death. Expand
Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus
factors1. Mutations in the connexin26 gene (GJB2), located on 13q12, are responsible for non-syndromic recessive and dominant forms of deafness2–4. Connexin-31 and connexin-32 have also beenExpand
GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak.
TLDR
It is proposed that the dyskinesias result from an exertion-induced energy deficit that may cause episodic dysfunction of the basal ganglia, and that the hemolysis with echinocytosis may result from alterations in intracellular electrolytes caused by a cation leak through mutant GLUT1. Expand
...
1
2
3
4
5
...