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Comparison of the Biodistribution and Tumor Targeting of Two 99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT
TLDR
The Nanobody fragments used here show high tumor uptake, low liver uptake, and rapid blood clearance, and Nanobodies are promising probes for noninvasive radioimmunodetection of specific targets early after administration.
Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma
TLDR
68Ga-HER2-Nanobody PET/CT is a safe procedure with a radiation dose comparable to other routinely used PET tracers, and tracer accumulation in HER2-positive metastases is high, compared with normal surrounding tissues, and warrants further assessment in a phase II trial.
Synthesis, Preclinical Validation, Dosimetry, and Toxicity of 68Ga-NOTA-Anti-HER2 Nanobodies for iPET Imaging of HER2 Receptor Expression in Cancer
TLDR
A new anti-HER2 PET tracer, 68Ga-NOTA-2Rs15d, was synthesized via a rapid procedure under mild conditions and showed high-specific-contrast imaging of HER2-positive tumors with no observed toxicity.
PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments
TLDR
18F radiosynthesis was optimized, providing an optimal probe for PET imaging of the tumor-promoting macrophage subpopulation in the tumor stroma, demonstrating the specificity of the 18F tracer for MMR and macrophages, respectively.
Nanobodies Targeting Mouse/Human VCAM1 for the Nuclear Imaging of Atherosclerotic Lesions
TLDR
The 99mTc-labeled, anti-VCAM1 nanobody cAbVCAM 1-5 allowed noninvasive detection of VCAM1 expression and displayed mouse and human cross-reactivity, demonstrating the potential of nanobodies as a new class of radiotracers for cardiovascular applications.
Nanobody-coupled microbubbles as novel molecular tracer.
TLDR
Using metabolic and site-specific biotinylation of nanobodies, a method to develop nanobody-coupled μBs was described and the application of VCAM-1-targeted μBs as novel molecular ultrasound contrast agent was demonstrated both in vitro and in vivo.
SPECT and PET amino acid tracer influx via system L (h4F2hc-hLAT1) and its transstimulation.
TLDR
2IT has a high affinity for h4F2hc-hLAT1, comparable to that of natural tyrosine, and its influx rate is transstimulated by intracellular amino acids, compared with that of IMT but lower than that of phenylalanine.
In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier.
TLDR
Data indicate that components of the glomerular filtration barrier may contribute to the dissociation of siRNA from its carrier, as was recently suggested for cationic cyclodextrin siRNA polyplexes.
Development of 177Lu-nanobodies for radioimmunotherapy of HER2-positive breast cancer: evaluation of different bifunctional chelators.
TLDR
The in-house developed anti-HER2 nanobody 2Rs15dHIS can be successfully labeled with (177) Lu using different bifunctional chelators, and both macrocyclic and acyclic chelator show high stability in time.
Optimal dose of 18F-FDG required for whole-body PET using an LSO PET camera
TLDR
The aim of this study was to determine the optimal dose of 18F-FDG required in order to achieve good-to-excellent image quality when a "3-min emission, 2-min transmission/bed position" protocol is used for an LSO PET camera.
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