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Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate
TLDR
It is suggested that glial glutamate transporters provide the majority of functional glutamate transport and are essential for maintaining low extracellular glutamate and for preventing chronic glutamate neurotoxicity. Expand
Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
TLDR
This work identifies the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricOSuric agents (which affect excretion of uric acid). Expand
Primary structure and functional characterization of a high-affinity glutamate transporter
TLDR
A complementary DNA encoding an electrogenic Na+ but not Cl−-dependent high-affinity glutamate transporter (named EAAC1) is isolated from rabbit small intestine by expression in Xenopus oocytes and transcripts are found in specific neuronal structures in the central nervous system as well as in the small intestine, kidney, liver and heart. Expand
Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)*
TLDR
In in vitro translation, LAT1 was shown to be a nonglycosylated membrane protein consistent with the property of 4F2 light chain, suggesting LAT1 is at least one of the proteins formerly referred to as 4F 2 light chain. Expand
Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter*
TLDR
The isolation of a novel complementary DNA from rat kidney that encodes a 551-amino acid residue protein (OAT1) with 12 putative membrane-spanning domains suggests that OAT1 is a multispecific organic anion transporter at the basolateral membrane of the proximal tubule. Expand
Expression cloning of a mammalian proton-coupled oligopeptide transporter
TLDR
The cloning and functional characterization of a H+-coupled transporter of oligopeptides and peptide-derived antibiotics from rabbit small intestine is reported, and the PepT1 primary structure is the first reported for a proton-Coupled organic solute transporter in vertebrates. Expand
CATs and HATs: the SLC7 family of amino acid transporters
TLDR
Members of the CAT family transport essentially cationic amino acids by facilitated diffusion with differential trans-stimulation by intracellular substrates and may regulate the rate of NO synthesis by controlling the uptake of l-arginine as the substrate for nitric oxide synthase (NOS). Expand
Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain*
TLDR
A cDNA encoding the new member of the multispecific organic anion transporter family, OAT3, was isolated by the reverse transcription-polymerase chain reaction cloning method and northern blot analysis revealed that rat Oat3 mRNA is expressed in the liver, brain, kidney, and eye. Expand
Cloning and Functional Characterization of a System ASC-like Na+-dependent Neutral Amino Acid Transporter*
TLDR
Functional characterization of ASCT2 provided fruitful information on the properties of substrate binding sites and the mechanisms of transport of Na+-dependent neutral and acidic amino acid transporter family, which would facilitate the structure-function analyses based on the comparison of the primary structures of AsCT2 and the other members of the family. Expand
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.
TLDR
An important role of hOAT3 in the excretion/detoxification of endogenous and exogenous organic anions in the kidney is suggested. Expand
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