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Comparison of the Biodistribution and Tumor Targeting of Two 99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT
TLDR
The Nanobody fragments used here show high tumor uptake, low liver uptake, and rapid blood clearance, and Nanobodies are promising probes for noninvasive radioimmunodetection of specific targets early after administration.
Improved quantification in single-pinhole and multiple-pinhole SPECT using micro-CT information
TLDR
Attenuation correction obtained from micro-CT data in combination with scatter correction allows accurate quantification in pinhole SPECT.
Non-invasive quantification of the beta cell mass by SPECT with 111In-labelled exendin
TLDR
These studies indicate that 111In-labelled exendin may be suitable for non-invasive quantification of BCM in vivo in a rodent model of beta cell loss and in patients with type 1 diabetes and healthy individuals.
Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.
TLDR
These findings provide preclinical proof of concept that anti-MMR nanobodies can be used to selectively target and image TAM subpopulations in vivo, and target pro-angiogenic MMR+ TAMs.
Phase I Study of 68Ga-HER2-Nanobody for PET/CT Assessment of HER2 Expression in Breast Carcinoma
TLDR
68Ga-HER2-Nanobody PET/CT is a safe procedure with a radiation dose comparable to other routinely used PET tracers, and tracer accumulation in HER2-positive metastases is high, compared with normal surrounding tissues, and warrants further assessment in a phase II trial.
Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells.
TLDR
The results demonstrate the involvement of exosome-mediated communication in BMSC-induced proliferation, migration, survival, and drug resistance of MM cells.
Synthesis, Preclinical Validation, Dosimetry, and Toxicity of 68Ga-NOTA-Anti-HER2 Nanobodies for iPET Imaging of HER2 Receptor Expression in Cancer
TLDR
A new anti-HER2 PET tracer, 68Ga-NOTA-2Rs15d, was synthesized via a rapid procedure under mild conditions and showed high-specific-contrast imaging of HER2-positive tumors with no observed toxicity.
PET Imaging of Macrophage Mannose Receptor–Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments
TLDR
18F radiosynthesis was optimized, providing an optimal probe for PET imaging of the tumor-promoting macrophage subpopulation in the tumor stroma, demonstrating the specificity of the 18F tracer for MMR and macrophages, respectively.
Nanobodies Targeting Mouse/Human VCAM1 for the Nuclear Imaging of Atherosclerotic Lesions
TLDR
The 99mTc-labeled, anti-VCAM1 nanobody cAbVCAM 1-5 allowed noninvasive detection of VCAM1 expression and displayed mouse and human cross-reactivity, demonstrating the potential of nanobodies as a new class of radiotracers for cardiovascular applications.
Nanobody-coupled microbubbles as novel molecular tracer.
TLDR
Using metabolic and site-specific biotinylation of nanobodies, a method to develop nanobody-coupled μBs was described and the application of VCAM-1-targeted μBs as novel molecular ultrasound contrast agent was demonstrated both in vitro and in vivo.
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