• Corpus ID: 46280636

SPECT and PET Amino Acid Tracer Influx via System L ( h 4 F 2 hc-h LAT 1 ) and Its Transstimulation

  title={SPECT and PET Amino Acid Tracer Influx via System L ( h 4 F 2 hc-h LAT 1 ) and Its Transstimulation},
  author={Tony Lahoutte and Vicky Caveliers and Simone Camargo and Raffaella Franca and Di Wang Pharm and Tamara Ramadan and Emilija Veljkovic and John Mertens and Axel Bossuyt and François Verrey},
System L amino acid transport is increased in various types of cancer. The tracer 123I-2-iodotyrosine (2IT), which is accumulated via system L, could thus serve to allow visualization of cancer in vivo. Here, we studied the transport of 125I-2IT by h4F2hc-hLAT1, the major transporter subserving system L in growing cells, using the Xenopus laevis oocyte expression system. We compared the apparent affinity of 125I-2IT with that of tyrosine, tested the influence of intracellular methionine… 

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