Rotenone

Known as: (1)Benzopyrano(3,4-b)furo(2,3-h)(1)benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R-(2alpha,6aalpha,12aalpha))-, Rotenone [Chemical/Ingredient] 
A botanical insecticide that is an inhibitor of mitochondrial electron transport.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and… (More)
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Highly Cited
2009
Highly Cited
2009
The systemic rotenone model of Parkinson's disease (PD) accurately replicates many aspects of the pathology of human PD and has… (More)
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Review
2006
Review
2006
Botanical insecticides have long been touted as attractive alternatives to synthetic chemical insecticides for pest management… (More)
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Highly Cited
2005
Highly Cited
2005
Paraquat, MPTP, and rotenone reproduce features of Parkinson's disease (PD) in experimental animals. The exact mechanisms by… (More)
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Highly Cited
2003
Highly Cited
2003
Inhibition of mitochondrial respiratory chain complex I by rotenone had been found to induce cell death in a variety of cells… (More)
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Highly Cited
2003
Highly Cited
2003
Exposure of rats to the pesticide and complex I inhibitor rotenone reproduces features of Parkinson's disease, including… (More)
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Highly Cited
2003
Highly Cited
2003
Previous studies demonstrated that chronic systemic exposure to the pesticide and mitochondrial toxin rotenone through jugular… (More)
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Highly Cited
2002
Highly Cited
2002
Rotenone (an inhibitor of mitochondrial NADH dehydrogenase, a naturally occurring toxin and a commonly used pesticide) appears to… (More)
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Highly Cited
2002
Highly Cited
2002
Skeletal muscle is strongly dependent on oxidative phosphorylation for energy production. Because the insulin resistance of… (More)
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Highly Cited
2000
Highly Cited
2000
The cause of Parkinson's disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other… (More)
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