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Biochemical, physiological and medical aspects of ubiquinone function.
This presentation is a brief review of current knowledge concerning some biochemical, physiological and medical aspects of the function of ubiquinone (coenzyme Q) in mammalian organisms. In additionExpand
The oxidative inactivation of mitochondrial electron transport chain components and ATPase.
Bovine heart submitochondrial particles (SMP) were exposed to continuous fluxes of hydroxyl radical (.OH) alone, superoxide anion radical (O2-) alone, or mixtures of .OH and O2-, by gamma radiolysisExpand
AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA
Preparations of rat-liver mitochondria catalyze the oxidation of exogenous NADH by added cytochrome c or ferricyanide by a reaction that is insensitive to the respiratory chain inhibitors, antimycinExpand
Mitochondria: a historical review
DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation.
Abstract Rat liver microsomes incubated in the presence of NADPH catalyze the oxidation of menadione (2-methyl-1,4-naphthoquinone) by two pathways: NADPH-cytochrome P-450 reductase and DT-diaphorase.Expand
Oxidative phosphorylation and photophosphorylation.
Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency
BACKGROUND The respiratory-chain deficiencies are a broad group of largely untreatable diseases. Among them, coenzyme Q10 (ubiquinone) deficiency constitutes a subclass that deserves early andExpand
Distribution and redox state of ubiquinones in rat and human tissues.
The distribution and redox state of ubiquinone in rat and human tissues have been investigated. A rapid extraction procedure and direct injection onto HPLC were employed. It was found in modelExpand
Mutagenicity of quinones: pathways of metabolic activation and detoxification.
The mutagenicity of various quinones, a class of compounds widely distributed in nature, is demonstrated in the Salmonella TA104 tester strain. The metabolic pathways by which four quinones,Expand
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