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The mitochondrial transporter family (SLC25): physiological and pathological implications
TLDR
The cloning and functional identification of many SLC25 genes has made it possible to identify the genes (and their defects) responsible for some diseases, e.g. Stanley syndrome and Amish microcephaly, and to characterize the function of the gene products and hence understand the molecular basis and the symptoms of the diseases.
Identification of the Mitochondrial ATP-Mg/Pi Transporter
TLDR
Because phosphate recycles via the phosphate carrier in mitochondria, the three isoforms of the ATP-Mg/Pi carrier are most likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria and hence for the variation in the matrix adanine nucleotide content, which has been found to change in many physiopathological situations.
UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation
TLDR
It is shown that UCP2 is a metabolite transporter that regulates substrate oxidation in mitochondria, and that it exports C4 metabolites from mitochondria to the cytosol in vivo and catalyzes an exchange of malate, oxaloacetate, and aspartate for phosphate.
Molecular identification of three Arabidopsis thaliana mitochondrial dicarboxylate carrier isoforms: organ distribution, bacterial expression, reconstitution into liposomes and functional
TLDR
It is proposed that plant DICs constitute the membrane component of several metabolic processes including the malate-oxaloacetate shuttle, the most important redox connection between the mitochondria and the cytosol.
Identification of a Novel Transporter for Dicarboxylates and Tricarboxylates in Plant Mitochondria
TLDR
The newly identified dicarboxylate-tricar boxylate carrier may play a role in important plant metabolic functions requiring organic acid flux to or from the mitochondria, such as nitrogen assimilation, export of reducing equivalents from the turbines, and fatty acid elongation.
Evolution, structure and function of mitochondrial carriers: a review with new insights.
TLDR
The predictive power of these triplets is assessed by comparing predictions with experimentally determined data for Arabidopsis MCs, and applied these predictions to the not yet functionally characterized mitochondrial carriers of the grass, Brachypodium distachyon, and the alga, Ostreococcus lucimarinus.
Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter
TLDR
The identification and functional reconstitution of Ant1p (Ypr128cp), a peroxisomal transporter in the yeast Saccharomyces cerevisiae, which has the characteristic sequence features of the mitochondrial carrier family is reported.
Citrin and aralar1 are Ca2+‐stimulated aspartate/glutamate transporters in mitochondria
TLDR
The results demonstrate that citrin and aralar1 are isoforms of the hitherto unidentified aspartate/glutamate carrier and explain why mutations in citrin cause type II citrullinemia in humans, and suggest a novel mechanism of Ca2+ regulation of the as partate/malate shuttle.
MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria
TLDR
It is shown that MTCH2/MIMP (mitochondrial carrier homologue 2/Met-induced mitochondrial protein), a novel truncated BID-interacting protein, is a surface-exposed outer mitochondrial membrane protein that facilitates the recruitment of tBID to mitochondria.
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