Recombinant Platelet Factor 4

Known as: rhPF4, CXCL4, Platelet Factor 4 
A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding… (More)
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Angiogenesis plays a pivotal role in many serious and life-threatening disorders (e.g., cancer, atherosclerosis, diabetes… (More)
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Review
2008
Review
2008
Platelets are a rich source of different chemokines and express chemokine receptors. CXCL4 is highly abundant in platelets and… (More)
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Review
2004
Review
2004
Protamine sulfate has been used for many years to reverse the effects of unfractionated heparin, but it can cause hemodynamic… (More)
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Highly Cited
2004
Highly Cited
2004
Platelet factor-4 (PF-4)/CXCL4 was the first chemokine described to inhibit neovascularization. Here, the product of the… (More)
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Highly Cited
2003
Highly Cited
2003
The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation… (More)
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Review
2003
Review
2003
Blood platelets play critical roles in hemostasis, providing rapid essential protection against bleeding and catalyzing the… (More)
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1995
1995
Protamine is the only available drug to reverse heparin-induced anticoagulation. Platelet factor 4 (PF4) is a basic polypeptide… (More)
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1995
1995
BACKGROUND When administered locally, recombinant platelet factor 4 (rPF4), a known angiogenesis inhibitor, has been shown to… (More)
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Highly Cited
1990
Highly Cited
1990
Recombinant human platelet factor-4 (rhPF4), purified from Escherichia coli, inhibited blood vessel proliferation in the chicken… (More)
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1990
1990
Platelet factor 4 (PF4) is a 70 amino acid protein released from the alpha-granules of platelets after activation. The exact… (More)
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