Skip to search formSkip to main contentSkip to account menu

Recombinant Platelet Factor 4

Known as: rhPF4, CXCL4, Platelet Factor 4 
A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding… 
National Institutes of Health

Related topics

Related topics

3 relations
NCIt Antineoplastic Agent Terminology

Broader (1)

Platelet Factor 4

Narrower (1)

Platelet Factor 4, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
CXCL4 and CXCL10 Predict Risk of Fatal Cerebral Malaria
Plasmodium falciparum in a subset of patients can lead to a diffuse encephalopathy known as cerebral malaria (CM). Despite… 
Highly Cited
2011
Highly Cited
2011
Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes
The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 are involved in variety of inflammatory disorders including… 
Highly Cited
2010
Highly Cited
2010
CXCL4 Downregulates the Atheroprotective Hemoglobin Receptor CD163 in Human Macrophages
Rationale: CXCL4 is a platelet-derived chemokine that promotes macrophage differentiation from monocytes. Deletion of the PF4… 
Highly Cited
2008
Highly Cited
2008
CXCL4‐induced migration of activated T lymphocytes is mediated by the chemokine receptor CXCR3
The chemokine CXCL4/platelet factor‐4 is released by activated platelets in micromolar concentrations and is a chemoattractant… 
Highly Cited
2005
Highly Cited
2005
CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production.
Review
2005
Review
2005
CXCR3-binding chemokines: novel multifunctional therapeutic targets.
The goal to attenuate inflammation without inducing generalized immunosuppression has focused the attention on chemokines, a… 
Highly Cited
2004
Highly Cited
2004
Platelets Release CXCL4L1, a Nonallelic Variant of the Chemokine Platelet Factor-4/CXCL4 and Potent Inhibitor of Angiogenesis
Platelet factor-4 (PF-4)/CXCL4 was the first chemokine described to inhibit neovascularization. Here, the product of the… 
Highly Cited
2003
Highly Cited
2003
An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4
The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation… 
Highly Cited
1995
Highly Cited
1995
Heparin Neutralization by Recombinant Platelet Factor 4 and Protamine
Protamine is the only available drug to reverse heparin-induced anticoagulation. Platelet factor 4 (PF4) is a basic polypeptide… 
Highly Cited
1991
Highly Cited
1991
Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity.
An analogue of human platelet factor 4 (PF4) lacking affinity for heparin was specifically designed to evaluate the importance of… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)