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HIV-1 Integrase Forms Stable Tetramers and Associates with LEDGF/p75 Protein in Human Cells*
The findings indicate that the minimal IN molecule in human cells is a homotetramer, suggesting that at least an octamer of IN is required to accomplish coordinated integration of both retroviral long terminal repeats and that LEDGF is a cellular factor involved in this process.
Gelatinase B functions as regulator and effector in leukocyte biology
Gelatinase B ablation in the mouse leads to altered bone remodeling and subfertility, results in resistance to several induced inflammatory or autoimmune pathologies, and indicates that the enzyme plays a crucial role in development and angiogenesis.
Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.
- P. E. Van den Steen, P. Proost, A. Wuyts, J. Van Damme, G. Opdenakker
- Biology, MedicineBlood
- 15 October 2000
A better understanding of regulator (IL-8) and effector molecules (gelatinase B) of neutrophils and of mechanisms underlying leukocytosis, shock syndromes, and stem cell mobilization by IL-8 is led to.
Degradation of the thiocarbamate herbicide EPTC (S-ethyl dipropylcarbamothioate) and biosafening by Rhodococcus sp. strain NI86/21 involve an inducible cytochrome P-450 system and aldehyde…
- I. Nagy, G. Schoofs, F. Compernolle, P. Proost, J. Vanderleyden, R. De Mot
- BiologyJournal of bacteriology
- 1 February 1995
It was demonstrated that the aldehyde dehydrogenase gene is widespread in the Rhodococcus genus, but the components of the cytochrome P-450 system are unique to Rhoditis sp.
cDNA cloning and molecular analysis of two self-incompatibility alleles from apple
The structural features of S-RNase deduced from a comparison of their sequences are discussed, and eight invariable cysteine residues, conserved regions around two histidines thought to play a role in RNA catalysis, and a number of other distinct residues are conserved between the apple S- RNases and similar proteins in the family Solanaceae.
Human monocyte chemotactic proteins‐2 and ‐3: structural and functional comparison with MCP‐1
In vitro, MCPs show different specific biological activities depending on the cell type and the chemokine tested, and MCP‐3 has the broadest range in that it activates monocytes, dendritic cells, lymphocytes, natural killer cells, eosinophils, basophil, and neutrophils.
Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties.
A negative feedback regulation by CD26/DPP IV in CX CR3-mediated chemotaxis without affecting the angiostatic potential of the CXCR3 ligands IP-10 and Mig is demonstrated.
Kinetic Investigation of Chemokine Truncation by CD26/Dipeptidyl Peptidase IV Reveals a Striking Selectivity within the Chemokine Family*
- A. Lambeir, P. Proost, I. De Meester
- Biology, ChemistryThe Journal of Biological Chemistry
- 10 August 2001
The steady-state catalytic parameters for a relevant selection of chemokines previously reported to alter their chemotactic behavior due to CD26/dipeptidyl peptidase IV-catalyzed truncation are determined and reveal a striking selectivity for stromal cell-derived factor-1α (CXCL12) and macrophage-derived chemokine (CCL22).
Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.
- P. E. Van den Steen, A. Wuyts, S. Husson, P. Proost, J. Van Damme, G. Opdenakker
- BiologyEuropean journal of biochemistry
- 1 September 2003
The conversion of mouse GCP-2/LIX by mouse gelatinase B is the fastest for any combination of chemokines and MMPs so far reported and extends the relevance of this proteolytic cleavage to the in vivo situation.
Amino-terminal Truncation of Chemokines by CD26/Dipeptidyl-peptidase IV
Proteolytic processing of RANTES by CD26/dipeptidyl-peptidase IV may constitute an important regulatory mechanism during anti-inflammatory and antiviral responses.