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Platelet Factor 4, human

Known as: Small-Inducible Cytokine B4, Small Inducible Cytokine Subfamily B, Member 4, Chemokine (C-X-C motif) Ligand 4 
Platelet factor 4 (101 aa, ~11 kDa) is encoded by the human PF4 gene. This protein is involved in the negative regulation of endothelial cell… 
National Institutes of Health

Related topics

Related topics

18 relations
Biologic DevelopmentBlood coagulationCentral Nervous SystemChemotaxis

Broader (2)

Platelet Factor 4Recombinant Platelet Factor 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies
The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an alarming rate. Type 2 diabetes mellitus… 
Highly Cited
2009
Highly Cited
2009
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice
Atherosclerosis is characterized by chronic inflammation of the arterial wall due to chemokine-driven mononuclear cell… 
Review
2006
Review
2006
Cancer CXC chemokine networks and tumour angiogenesis.
Highly Cited
2005
Highly Cited
2005
Laboratory testing for the antibodies that cause heparin-induced thrombocytopenia: how much class do we need?
Highly Cited
2004
Highly Cited
2004
Platelets Release CXCL4L1, a Nonallelic Variant of the Chemokine Platelet Factor-4/CXCL4 and Potent Inhibitor of Angiogenesis
Platelet factor-4 (PF-4)/CXCL4 was the first chemokine described to inhibit neovascularization. Here, the product of the… 
Highly Cited
2000
Highly Cited
2000
Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.
Chemokines are mediators in inflammatory and autoimmune disorders. Aminoterminal truncation of chemokines results in altered… 
Highly Cited
1996
Highly Cited
1996
Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor…
Pre-B-cell growth-stimulating factor/ stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group of chemokines that… 
Highly Cited
1995
Highly Cited
1995
Platelet Factor-4 Inhibits the Mitogenic Activity of VEGF121 and VEGF165 Using Several Concurrent Mechanisms (*)
The 121-amino acid form of vascular endothelial growth factor (VEGF121) and the 165-amino acid form (VEGF165) are mitogenic for… 
Highly Cited
1990
Highly Cited
1990
Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides.
Recombinant human platelet factor-4 (rhPF4), purified from Escherichia coli, inhibited blood vessel proliferation in the chicken… 
Highly Cited
1985
Highly Cited
1985
γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins
Interferons are a family of proteins first identified by their ability to induce cellular resistance to infection by many viruses… 
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