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Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation*
- E. Le Poul, Cécile Loison, +9 authors M. Detheux
- Biology, MedicineJournal of Biological Chemistry
- 11 July 2003
The pharmacology of GPR43 matches indeed the effects of SCFAs on neutrophils, in terms of intracellular Ca2+ release and chemotaxis, and might constitute a target allowing us to modulate immune responses in these pathological situations.
The CC chemokine CCL20 and its receptor CCR6.
- E. Schutyser, S. Struyf, J. Van Damme
- Biology, MedicineCytokine & growth factor reviews
- 1 October 2003
The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells (DC), effector/memory T- cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis.
The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis (*)
- R. Strieter, P. Polverini, +10 authors A. Shanafelt
- Biology, MedicineThe Journal of Biological Chemistry
- 10 November 1995
A functional role of the ELR motif is suggested in determining the angiogenic or angiostatic potential of CXC chemokines, supporting the hypothesis that the net biological balance between angiogenicity and angiOSTatic CXCs may play an important role in regulating overall angiogenesis.
Macrophage inflammatory protein-1.
Different aspects of human and mouse MIP-1alpha and Mip-1beta are discussed, including their protein and gene structures, their regulated production, their receptor usage and biological activities and their role in several pathologies including HIV-1 infection.
Gelatinase B functions as regulator and effector in leukocyte biology
- G. Opdenakker, P. E. Van den Steen, +5 authors J. Van Damme
- Biology, MedicineJournal of leukocyte biology
- 1 June 2001
Gelatinase B ablation in the mouse leads to altered bone remodeling and subfertility, results in resistance to several induced inflammatory or autoimmune pathologies, and indicates that the enzyme plays a crucial role in development and angiogenesis.
The role of CXC chemokines and their receptors in cancer.
The role of CXC chemokines and their receptors in tumorigenesis, including angiogenesis, attraction of leukocytes to tumor sites and induction of tumor cell migration and homing in metastatic sites is discussed.
Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.
- P. E. Van den Steen, P. Proost, A. Wuyts, J. Van Damme, G. Opdenakker
- Biology, MedicineBlood
- 15 October 2000
A better understanding of regulator (IL-8) and effector molecules (gelatinase B) of neutrophils and of mechanisms underlying leukocytosis, shock syndromes, and stem cell mobilization by IL-8 is led to.
CD26, let it cut or cut it down.
It is argued that a multidisciplinary approach might reveal the molecular events underlying the role of CD26 in HIV infection and immune, inflammatory and endocrine responses.
Response of serum interleukin-6 in patients undergoing elective surgery of varying severity.
The results are consistent with a role for interleukin-6 in the induction of C-reactive protein synthesis, and it is concluded that seruminterleuk in-6 is a sensitive, early marker of tissue damage.
Involvement of Sialoadhesin in Entry of Porcine Reproductive and Respiratory Syndrome Virus into Porcine Alveolar Macrophages
- N. Vanderheijden, P. Delputte, +4 authors H. Nauwynck
- Biology, MedicineJournal of Virology
- 1 August 2003
The ability of porcine sialoadhesin to mediate endocytosis was demonstrated by specific internalization of MAb41D3 into PAM and results show that sialoadedhesin is involved in the entry process of PRRSV in PAM.