Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation*
The pharmacology of GPR43 matches indeed the effects of SCFAs on neutrophils, in terms of intracellular Ca2+ release and chemotaxis, and might constitute a target allowing us to modulate immune responses in these pathological situations.
The CC chemokine CCL20 and its receptor CCR6.
Macrophage inflammatory protein-1.
The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis (*)
- R. Strieter, P. Polverini, A. Shanafelt
- Biology, MedicineJournal of Biological Chemistry
- 10 November 1995
A functional role of the ELR motif is suggested in determining the angiogenic or angiostatic potential of CXC chemokines, supporting the hypothesis that the net biological balance between angiogenicity and angiOSTatic CXCs may play an important role in regulating overall angiogenesis.
Gelatinase B functions as regulator and effector in leukocyte biology
Gelatinase B ablation in the mouse leads to altered bone remodeling and subfertility, results in resistance to several induced inflammatory or autoimmune pathologies, and indicates that the enzyme plays a crucial role in development and angiogenesis.
The role of CXC chemokines and their receptors in cancer.
CD26, let it cut or cut it down.
Involvement of Sialoadhesin in Entry of Porcine Reproductive and Respiratory Syndrome Virus into Porcine Alveolar Macrophages
The ability of porcine sialoadhesin to mediate endocytosis was demonstrated by specific internalization of MAb41D3 into PAM and results show that sialoadedhesin is involved in the entry process of PRRSV in PAM.
Murine CXCR1 Is a Functional Receptor for GCP-2/CXCL6 and Interleukin-8/CXCL8*
- Xuedong Fan, Andriani C. Patera, R. Hipkin
- Biology, ChemistryJournal of Biological Chemistry
- 20 April 2007
This report represents the first description of a functional CX CR1-like receptor in rodents and shows concomitant elevation of mCXCR1 and its proposed major ligand, GCP-2, positively correlated with paw swelling in murine collagen-induced arthritis.
Response of serum interleukin-6 in patients undergoing elective surgery of varying severity.
The results are consistent with a role for interleukin-6 in the induction of C-reactive protein synthesis, and it is concluded that seruminterleuk in-6 is a sensitive, early marker of tissue damage.