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Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis.
TLDR
It is demonstrated that a population of human CD45(+)Col I(+)CXCR4(+) circulating fibrocytes migrates in response to CXCL12 and traffics to the lungs in a murine model of bleomycin-induced pulmonary fibrosis.
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.
TLDR
The results imply pathogenic roles for specific chemokine-chemokine receptor interactions in MS and suggest new molecular targets for therapeutic intervention.
The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis (*)
TLDR
A functional role of the ELR motif is suggested in determining the angiogenic or angiostatic potential of CXC chemokines, supporting the hypothesis that the net biological balance between angiogenicity and angiOSTatic CXCs may play an important role in regulating overall angiogenesis.
CXC chemokines in angiogenesis.
Interleukin-8 as a macrophage-derived mediator of angiogenesis.
TLDR
A function for macrophage-derived IL-8 in angiogenesis-dependent disorders such as rheumatoid arthritis, tumor growth, and wound repair is suggested.
Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome.
TLDR
IL-8 and ENA-78 were the cytokines most strongly and consistently correlated with PMN concentrations in the lung fluids of patients with ARDS, and the correlations were independent of the other cytokines or coexisting lung infection.
The CXC Chemokine Receptor 2, CXCR2, Is the Putative Receptor for ELR+ CXC Chemokine-Induced Angiogenic Activity1
TLDR
It is found that microvascular endothelial cell chemotaxis in response to ELR+ CXC chemokines was inhibited by anti-CXCR2 Abs, suggesting a role for G protein-linked receptor mechanisms in this biological response.
Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.
TLDR
F-IPF have a striking defect in their capacity to synthesize the antiinflammatory and antifibrogenic molecule PGE2, apparently because of a diminished induction of COX-2 protein, which may contribute to the inflammatory and fibrogenic response in IPF.
An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.
TLDR
It is demonstrated that MIP-1 alpha plays an important role in directing the chemoattraction of mononuclear inflammatory cells in the T cell-mediated autoimmune disease, EAE.
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury.
TLDR
Increased expression of KC/CXCL1 and MIP-2/C XCL2/3 and their interaction with CXCR2 are important in the pathogeneses of VILI, and in vivo inhibition of CXC chemokine ligand interactions led to a marked reduction in neutrophil sequestration and lung injury.
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