Platelet Factor 4

Known as: platelet factor IV, gamma Thromboglobulin, Heparin Neutralizing Protein 
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Activated platelets, which release platelet factor 4 (PF4) are present in patients with atherosclerosis. To date, no direct in… (More)
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Highly Cited
2005
Highly Cited
2005
Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating IgG antibodies that recognize platelet factor 4 (PF4… (More)
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Highly Cited
2003
Highly Cited
2003
Emerging evidence supports a role for platelets in the progression of atherosclerosis in addition to an involvement in thrombotic… (More)
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Highly Cited
2002
Highly Cited
2002
Platelets share structural and functional similarities with granulocytes known to participate in antimicrobial host defense. To… (More)
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Highly Cited
2000
Highly Cited
2000
Unstimulated monocytes rapidly undergo physiological changes resulting in programmed cell death (apoptosis) while stimuli… (More)
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Highly Cited
1998
Highly Cited
1998
Platelet factor 4 (PF-4) inhibits angiogenesis in vitro and in vivo. The mechanism of inhibition is poorly understood. We have… (More)
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Highly Cited
1997
Highly Cited
1997
Clinical depression has recently been recognized as an independent risk factor for cardiac mortality in patients after myocardial… (More)
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Highly Cited
1995
Highly Cited
1995
IP-10 is a member of the chemokine family of cytokines and is induced in a variety of cells in response to interferon gamma and… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND As clinical diagnosis of heparin-associated thrombocytopenia (HAT) is often difficult, confirmation by sensitive… (More)
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Highly Cited
1994
Highly Cited
1994
Heparin-induced thrombocytopenia/thrombosis (HITP) is thought to be mediated by immunoglobulins that activate platelets in the… (More)
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