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Getting to the site of inflammation: the leukocyte adhesion cascade updated
This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade. Expand
Development of Monocytes, Macrophages, and Dendritic Cells
The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice. Expand
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
It is shown that the ER isoform, ERα, binds in a ligand-dependent manner to the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI(3)K). Expand
Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.
It is shown that IL-17, a cytokine that regulates granulopoiesis through G-CSF, is made by gammadelta T cells and unconventional alphabeta T cells, which are expanded in mice that lack leukocyte adhesion molecules, which have neutrophilia and defective neutrophil trafficking. Expand
Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice.
Homing experiments demonstrated that L-selectin plays an essential role in leukocyte homing to lymphoid tissues and sites of inflammation and significant defects inLeukocyte rolling and neutrophil migration into the peritoneum in response to an inflammatory stimulus were observed. Expand
Immune and inflammatory mechanisms of atherosclerosis (*).
This review summarizes the current understanding of inflammatory and immune mechanisms in atherosclerosis and indicates that Regulatory T cells and B1 cells secreting natural antibodies are atheroprotective. Expand
Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation.
Inhibition of platelet-neutrophil aggregation improved gas exchange, reduced neutrophil recruitment and permeability, and prolonged survival, and these findings may translate into improved clinical treatments for ALI. Expand
Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
The results indicate that circulating activated platelets and platelet–leukocyte/monocyte aggregates promote formation of atherosclerotic lesions. Expand
The role of selectins in inflammation and disease.
  • K. Ley
  • Biology, Medicine
  • Trends in molecular medicine
  • 1 June 2003
Improvements in the efficiency, availability, specificity and pharmacokinetics of selectin inhibitors, and specialized application routes and schedules, hold promise for therapeutic indications. Expand
Platelet-neutrophil-interactions: linking hemostasis and inflammation.
Platelets are essential for primary hemostasis, but they also play an important pro-inflammatory role and are important amplifiers of acute inflammation. Expand